| DOI | Trouver le DOI : https://doi.org/10.1111/j.1574-695X.2008.00416.x |
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| Auteur | Rechercher : Altman, Eleonora1; Rechercher : Chandan, Vandana1; Rechercher : Larocque, Suzon1; Rechercher : Aubry, Annie1; Rechercher : Logan, Susan M.1; Rechercher : Vinogradov, Evgeny1; Rechercher : Li, Jianjun1 |
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| Affiliation | - Conseil national de recherches du Canada. Institut des sciences biologiques du CNRC
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| Format | Texte, Article |
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| Sujet | Helicobacter pylori; lipopolysaccharide; structure; colonization |
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| Résumé | The outer core region of Helicobacter pylori lipopolysaccharide of the majority of isolates contains an a-1,6-glucan polymer synthesized by the product of the HP0159 ORF. Structural studies carried out on HP0159 lipopolysaccharide mutants by a combination of chemical methods, mass spectrometry and nuclear magnetic resonance spectroscopy confirmed that insertional inactivation of HP0159 gene in H. pylori strains 26695 and SS1 resulted in formation of a truncated lipopolysaccharide molecule characterized by the presence of a terminal DD-heptose residue in the side-chain outer core fragment and maintaining an inner core backbone structure compared with the wild-type Lewis antigen-expressing strains. Colonization studies with HP0159 mutants of two mouse-colonizing strains, SS1 and M6, confirmed their inability to successfully colonize the murine stomach. |
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| Date de publication | 2008-06-28 |
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| Dans | |
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| Langue | anglais |
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| Numéro du CNRC | ALTMAN2008A |
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| Numéro NPARC | 9362157 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 3a65e533-129e-488d-ba8f-96b89270327f |
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| Enregistrement créé | 2009-07-10 |
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| Enregistrement modifié | 2020-04-15 |
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