| Téléchargement | - Voir le manuscrit accepté : Towards Inter- and Intra- Cellular Protein Interaction Analysis: Applying the Betweenness Centrality Graph Measure for Node Importance (PDF, 541 Kio)
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| DOI | Trouver le DOI : https://doi.org/10.1063/1.3663481 |
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| Auteur | Rechercher : Barton, Alan J.1; Rechercher : Haqqani, Arsalan S. |
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| Affiliation | - Conseil national de recherches du Canada. Institut de technologie de l'information du CNRC
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| Format | Texte, Article |
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| Conférence | International Conference on Applied Mathematics, Modeling and Computational Science (AMMCS), Waterloo, Ontario, Canada, July 25-29, 2011, Waterloo, Ontario |
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| Sujet | Protein-protein Interactions; Relevant Proteins; Network Analysis; Betweenness Centrality; Cancer; Blood-Brain Barrier |
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| Résumé | Three public biological network data sets (KEGG, GeneRIF and Reactome) are collected and described. Two problems are investigated (inter- and intra- cellular interactions) via augmentation of the collected networks to the problem specific data. Results include an estimate of the importance of proteins for the interaction of inflammatory cells with the bloodbrain barrier via the computation of Betweenness Centrality. Subsequently, the interactions may be validated from a number of differing perspectives; including comparison with (i) existing biological results, (ii) the literature, and (iii) new hypothesis driven biological experiments. Novel therapeutic and diagnostic targets for inhibiting inflammation at the blood-brain barrier in a number of brain diseases including Alzheimer’s disease, stroke and multiple sclerosis are possible. In addition, this methodology may also be applicable towards investigating the breast cancer tumour microenvironment. |
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| Date de publication | 2011 |
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| Série | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro NPARC | 18608905 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 3eb6f465-0ee6-4d69-a072-aeeadc9e6598 |
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| Enregistrement créé | 2011-09-21 |
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| Enregistrement modifié | 2020-04-21 |
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