| DOI | Trouver le DOI : https://doi.org/10.1016/0014-2999(87)90514-0 |
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| Auteur | Rechercher : Dresel, Peter E.; Rechercher : Knickle, Leah1 |
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| Affiliation | - Conseil national de recherches du Canada. Développement des cultures et des ressources aquatiques
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| Format | Texte, Article |
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| Sujet | Aorta; Cytochalasin-B; EDRF; Histamine; Noradrenaline; Phloretin; Sugar transport; (Contraction, Relaxation) |
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| Résumé | Cytochalasin-B (20 μM) and phloretin (100 μM) blocked by more than 80% the contractile responses to calcium ions in partially depolarized rabbit aortic strips. Both also blocked, but only by approximately 50%, the responses to noradrenaline and histamine in normal calcium medium. The responses to these agonists in calcium-free EGTA medium were also blocked partially. Cytochalasin-B partially blocked the acetylcholine-induced relaxation of aortic strips precontracted with phenylephrine but not the relaxation due to nitroglycerine or compound A 23187. The relaxation due to isoprenaline was potentiated by cytochalasin B. Since both compounds are known to block hexose transport but share no other known effects, it is suggested that a glycolytic intermediate could be required for the contraction in response to calcium. However, the concentrations of cytochalasin-B required for these effects were somewhat greater than those usually required to block hexose transport. |
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| Date de publication | 1987-12 |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro NPARC | 23000932 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 4426b491-aa17-46a1-a7f6-6a3efbd55cb4 |
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| Enregistrement créé | 2016-11-17 |
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| Enregistrement modifié | 2020-03-17 |
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