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Gouvernement du Canada / Government of Canada

Recherche

Hepatitis C virus and microRNAs: MiRed in a host of possibilities

Par Conseil national de recherches du Canada

DOITrouver le DOI : https://doi.org/10.1016/j.coviro.2014.03.004
AuteurRechercher : 1; Rechercher : ; Rechercher : ; Rechercher : 1
Affiliation
  1. Conseil national de recherches du Canada. Dispositifs médicaux
FormatTexte, Article
SujetmicroRNA; biogenesis; disease association; disease course; hepatitis C; Hepatitis C virus; host pathogen interaction; life cycle; liver cell carcinoma; liver fibrosis; pathogenesis; regulatory mechanism; steatosis; virus genome; virus immunity
Résumé
It is well-established that the host microRNA (miRNA) milieu has a significant influence on the etiology of disease. In the context of viruses, such as hepatitis C virus (HCV), microRNAs have been shown to influence viral life cycles both directly, through interactions with the viral genome, and indirectly, through regulation of critical virus-associated host pathways. Several miRNA profiling studies have demonstrated that HCV infection aberrantly regulates a significant number of human miRNA. However, the biological relevance of these modulations remains poorly understood. In this review, we summarize recent research that has shed light on the pro-viral and anti-viral roles of HCV-induced changes in human miRNA expression and their significance in the development of HCV related sequelae and response to therapy.
Date de publication
Dans
  • Current Opinion in Virology 7, nº 1 (août 2014) : 1–10.
Langueanglais
Publications évaluées par des pairsOui
Numéro NPARC21272668
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Identificateur de l’enregistrement4b9379a7-c00e-4e97-95ee-2fb4f0a0e8aa
Enregistrement créé2014-12-03
Enregistrement modifié2020-04-22
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