Noninvasive assessment of cardiac ischemic injury using 87Rb and 23Na MR imaging, 31P MR, and optical spectroscopy

Par Conseil national de recherches du Canada

DOI	Trouver le DOI : https://doi.org/10.1002/1522-2594(200012)44:6<899::AID-MRM11>3.0.CO;2-7
Auteur	Rechercher : Kupriyanov, V. V.¹; Rechercher : Dai, G.¹; Rechercher : Shaw, A.¹; Rechercher : Sun, J.¹; Rechercher : Jilkina, O.; Rechercher : Luo, Z.¹; Rechercher : Mantsch, H.¹; Rechercher : Deslauriers, R.¹
Affiliation	Conseil national de recherches du Canada. Institut du biodiagnostic du CNRC
Format	Texte, Article
Sujet	cardiac ischemia; infarct; MR imaging and spectroscopy; optical spectroscopy; heart
Résumé	The aim of the study was to compare and analyze different noninvasive indices of cell damage in the isolated pig heart model of regional ischemia. We used 23Na and 87Rb MR imaging to evaluate Na+/K+ balance, 31P MR spectroscopy to measure energetics, and optical spectroscopy to assess oxymyoglobin (MbO2). Hearts were subjected to 120-min occlusion of the left anterior descending artery and were then reperfused for 120 min. Reperfusion resulted in an increase in 23Na (37 ± 18% of the posterior wall) and decrease in 87Rb (55 ± 15%) image intensities, partial recovery of PCr, ATP, the total phosphates, and MbO2 in the anterior wall. The above changes are consistent with the irreversible cell damage in the anterior wall, confirmed by lack of staining with triphenyltetrazolium chloride. Changes in Na+ and Rb+ in the infarct area inversely correlated and their ratio is a more sensitive index of cell injury than either of them alone.
Date de publication	2000-12-01
Maison d’édition	Wiley-Liss, Inc.
Dans	Magnetic Resonance in Medicine 44, nº 6 (1 décembre 2000) : 899–908.
Langue	anglais
Publications évaluées par des pairs	Oui
Numéro du CNRC	NRC-IBD-1848
Numéro NPARC	9148277
Exporter la notice	Exporter en format RIS
Signaler une correction	Signaler une correction (s'ouvre dans un nouvel onglet)
Identificateur de l’enregistrement	5671a3fe-05dc-47d6-8475-6d0d8f36b63e
Enregistrement créé	2009-06-25
Enregistrement modifié	2023-06-20

Date de modification :: 2024-06-29