| DOI | Trouver le DOI : https://doi.org/10.1016/0022-2860(94)08235-9 |
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| Auteur | Rechercher : Shaw, A.1; Rechercher : Perczel, A.; Rechercher : Mantsch, H. H.1; Rechercher : Fasman, G. D. |
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| Affiliation | - Conseil national de recherches du Canada. Institut du biodiagnostic du CNRC
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| Format | Texte, Article |
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| Sujet | ϵ-Aca = ϵ-aminocaproic acid; δ-Ava = δ-aminovaleric acid; vCPA = cyclo[ϵ-aminocaproyl-l-prolyl-l-alanine]; CPTOBz = cyclo[ϵ-aminocaproyl-l-prolyl-l-threonineOBz], (CPA)2; CPTOBz = cyclo[ϵ-aminocaproyl-l-prolyl-l-threonineOBz], (CPA)2; CPA)2 = cyclo[ϵ-aminocaproyl-l-prolyl-l-alanyl-ϵ-aminocaproyl-l-prolyl-l-alanine] |
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| Résumé | Infrared spectra are reported in the amide I absorption region for some cyclic peptides of the general formula cyclo[ϵ-Aca-Pro-Xxx] (ϵ-Aca = ϵ-aminocaproyl; Xxx = Ala, ThrOBz) and the corresponding “dimers” cyclo[ϵ-Aca-Pro-Xxx-ϵ-Aca-Pro-Xxx] dissolved in D₂O and acetonitrile. The acetonitrile solution spectra are very different from those measured in D₂O. In particular, the D₂O solution spectra exhibit amide I absorptions at exceptionally low frequencies (1595–1600 cm⁻¹). The infrared spectra are interpreted as indicating an unusual D₂O solution structure involving three-centered hydrogen bonding to the Aca carbonyl group, two amide protons interacting with the C=O group to simultaneously close both a γ-turn and a β-turn. The acetonitrile solution spectra are interpreted as reflecting hydrogen-bonding characteristics of a β-turn, with certain compounds also showing absorptions that suggest the presence of other hydrogen-bonded (γ-turn) conformers. |
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| Date de publication | 1994-07 |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro du CNRC | NRC-IBD-105 |
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| Numéro NPARC | 9742634 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 598a5285-dc45-4997-a3bc-f6da922ad65c |
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| Enregistrement créé | 2009-07-17 |
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| Enregistrement modifié | 2020-04-27 |
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