| Autre titre | Abstract 65: DNA methylation at ABCG1 and long-term changes in adiposity in response to diet interventions: the POUNDS lost trial |
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| Téléchargement | - Voir les données supplémentaires : DNA methylation at ABCG1 and long-term changes in adiposity in response to diet interventions: the POUNDS lost trial (JPG, 115 Kio)
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| DOI | Trouver le DOI : https://doi.org/10.1161/circ.147.suppl_1.65 |
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| Auteur | Rechercher : Li, Xiang; Rechercher : Shao, Xiaojian1; Rechercher : Xue, Qiaochu; Rechercher : Kou, Minghao; Rechercher : Grundberg, Elin; Rechercher : Bray, George A; Rechercher : Sacks, Frank M; Rechercher : Qi, Lu |
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| Affiliation | - Conseil national de recherches du Canada. Technologies numériques
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| Format | Texte, Résumé |
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| Conférence | American Heart Association's Epidemiology and Prevention/Lifestyle and Cardiometabolic Health 2023 Scientific Sessions, March 1-3, 2023, Boston, Massachusetts, United States |
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| Résumé | Introduction: Epigenome-wide association studies identified that DNA methylation (DNAm) at the ABCG1 gene (cg06500161) was associated with obesity. However, little is known about whether DNAm at ABCG1 is associated with long-term changes in adiposity and body fat distribution in response to dietary weight-loss interventions.
Hypothesis: We hypothesized that participants with varying DNAm at ABCG1 might respond differently to dietary weight-loss interventions on long-term changes in adiposity and body fat distribution.
Methods: The current study included 673 participants with overweight/obesity, who were randomly assigned to 1 of 4 diets varying in macronutrient components. Blood DNAm level was profiled by a high-resolution methylC-capture sequencing at baseline. The regional DNAm at ABCG1 was defined as the average methylation level over CpGs within ± 250 bp of cg06500161. Two-year changes in adiposity and Computed Tomography (CT)-measured body fat distribution were calculated.
Results: We found that regional DNAm at ABCG1 significantly interacted with dietary protein intake on long-term changes in body weight and waist circumference (WC) at 6 months and 2 years (P-interaction < 0.05 for all, Figure ). Among participants assigned to an average-protein (15%) diet, lower regional DNAm at ABCG1 was associated with greater reductions in body weight and WC at 6 months and 2 years, while opposite associations were found among those assigned to a high-protein (25%) diet. Similar interactions were also observed for body fat distribution, including visceral adipose tissue, subcutaneous adipose tissue, deep subcutaneous adipose tissue, and total adipose tissue at 6 months and 2 years (P-interaction < 0.05 for all).
Conclusion: Our data indicate that DNAm at ABCG1 interacted with dietary protein intake on long-term changes in adiposity and body fat distribution. Participants with hypomethylation at ABCG1 benefited more in long-term improvement in adiposity and body fat distribution by consuming an average-protein diet. |
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| Date de publication | 2023-03-14 |
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| Maison d’édition | Ovid Technologies (Wolters Kluwer Health)
American Heart Association |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 5d9dabf8-4f53-4018-bdc2-168696a8d030 |
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| Enregistrement créé | 2023-10-16 |
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| Enregistrement modifié | 2023-12-01 |
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