Lipid-induced changes in the secondary structure of snake venom cardiotoxins

Par Conseil national de recherches du Canada

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DOI	Trouver le DOI : https://doi.org/10.1016/S0021-9258(19)35423-7
Auteur	Rechercher : Surewicz, Witold K.¹; Rechercher : Stepanik, Terry M.¹; Rechercher : Szabo, Arthur G.¹; Rechercher : Mantsch, Henry H.¹
Affiliation	Conseil national de recherches du Canada
Format	Texte, Article
Résumé	The secondary structures of three snake venom cardiotoxins (from Hemachatus hemachatus, Naja naja atra, and Naja naja naja), in aqueous solution and in a lipid-bound form, were investigated by Fourier-transform infrared spectroscopy. The conformation-sensitive protein infrared bands in the amide I region were analyzed using deconvolution and band-fitting procedures. The spectra of the three cardiotoxins in aqueous buffer are very similar; they indicate a high content of both antiparallel beta-sheet structure and unordered conformation. Moreover, component bands characteristic of turns can also be identified. The binding of cardiotoxins to bilayers of dimyristoylphosphatidyl-glycerol results in an increased content of a beta-structure at the expense of the nonordered conformation. It is suggested that lipid-induced conformational transitions to a beta-structure, similar to that observed with cardiotoxins, may be operative also in membrane interaction of other proteins and peptides, particularly with those which have a small tendency to form alpha-helices.
Date de publication	1988-01-15
Maison d’édition	The American Society for Biochemistry and Molecular Biology Elsevier
Licence	Creative Commons, Attribution 4.0 Générique (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/deed.fr
Dans	The Journal of Biological Chemistry 263, nº 2 (15 janvier 1988) : 786–790.
Langue	anglais
Publications évaluées par des pairs	Oui
Numéro NPARC	23001353
Exporter la notice	Exporter en format RIS
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Identificateur de l’enregistrement	67a5402c-b2b9-4e3d-b964-90246af114cf
Enregistrement créé	2017-01-23
Enregistrement modifié	2021-07-30

Date de modification :: 2025-01-02