| DOI | Trouver le DOI : https://doi.org/10.1038/nn815 |
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| Auteur | Rechercher : Lembo, Paloa M. C.; Rechercher : Grazzini, Eric; Rechercher : Groblewski, Thierry; Rechercher : O'Donnell, Dajan; Rechercher : Roy, Marie-Odile; Rechercher : Zhang, Ji; Rechercher : Hoffert, Cyrla; Rechercher : Cao, Jack; Rechercher : Schmidt, Ralf; Rechercher : Pelletier, Manon; Rechercher : Labarre, Maryse; Rechercher : Gosselin, Mylene; Rechercher : Fortin, Yves1; Rechercher : Banville, Denis1; Rechercher : Shen, S. H.1; Rechercher : Ström, Peter; Rechercher : Payza, Kemal; Rechercher : Dray, Andy; Rechercher : Walker, Philippe; Rechercher : Ahmad, Sultan |
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| Affiliation | - Conseil national de recherches du Canada. Institut de recherche en biotechnologie du CNRC
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| Format | Texte, Article |
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| ISSN | 10976256 |
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| Sujet | pharmaceutical |
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| Résumé | Several peptide fragments are produced by proteolytic cleavage of the opioid peptide precursor proenkephalin A, and among these are a number of enkephalin fragments, in particular bovine adrenal medulla peptide 22 (BAM22). These peptide products have been implicated in diverse biological functions, including analgesia. We have cloned a newly identified family of ‘orphan’ G protein– coupled receptors (GPCRs) and demonstrate that BAM22 and a number of its fragments bind to and activate these receptors with nanomolar affinities. This family of GPCRs is uniquely localized in the human and rat small sensory neuron, and we called this family the sensory neuron–specific G protein–coupled receptors (SNSRs). Receptors of the SNSR family are distinct from the traditional opioid receptors in their insensitivity to the classical opioid antagonist naloxone and poor activation by opioid ligands. The unique localization of SNSRs and their activation by proenkephalin A peptide fragments indicate a possible function for SNSRs in sensory neuron regulation and in the modulation of nociception. |
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| Date de publication | 2002-02-19 |
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| Dans | |
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| Langue | anglais |
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| Identificateur | 18344525 |
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| Numéro du CNRC | 44832 |
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| Numéro NPARC | 3539825 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 6d5fca77-4775-450c-a2ca-48ae7ae27c7e |
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| Enregistrement créé | 2009-03-01 |
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| Enregistrement modifié | 2020-03-30 |
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