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Further studies of a new vitamin E analogue more active than α-tocopherol in the rat curative myopathy bioassay

Par Conseil national de recherches du Canada

DOITrouver le DOI : https://doi.org/10.1016/0014-5793(90)80288-T
AuteurRechercher : 1; Rechercher : 1; Rechercher : 1; Rechercher : 1
Affiliation
  1. Conseil national de recherches du Canada
FormatTexte, Article
Sujetalpha tocopherol; alpha tocopherol derivative; antioxidant; animal cell; chemical structure; myopathy; rat; stereoisomerism; biological assay; chemistry; male; pyruvate kinase; rats; rats, inbred strains; stereoisomerism; support, Non-U.S. Gov't; vitamin E; vitamin E deficiency; animalia
Résumé
The bioactivities of the acetates of 2R,4'R,8'R- and 25,4'R,8'R-2,4,6,7-tetramethyl-2-(4',8',12'-trimethyltridecyl)-5-hydroxy-3,4-dihydrobenzofuran (RRR- and SRR-1-Ac) have been measured in the rat curative myopathy bioassay and compared with the RRR and SRR stereoisomers of α-tocopheryl acetate (RRR- and SRR-2-Ac). Each stereoisomer of 1 is only slightly more active than the corresponding stereoisomer of 2(RRR-1-Ac/RRR-2-Ac = 110; SRR-1-Ac/SRR-2-Ac = 1.16). This finding contrasts with our earlier finding [(1986) FEBS Lett. 205, 117 120], confirmed in the present study, that all-rac-1-Ac is 1.5-1.9 as active as all-rac-2-Ac. We suggest that the stereochemistry (S vs R) at the 4' and 8' tail carbons is of less biological importance in 1 than in 2. © 1990.
Date de publication
Dans
  • FEBS Letters 267, nº 1 (1990) : 63–65.
Langueanglais
Publications évaluées par des pairsOui
Numéro NPARC21276690
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Identificateur de l’enregistrement6e9cc522-dc37-434a-bb28-10a7b6602dc3
Enregistrement créé2015-10-13
Enregistrement modifié2020-03-17
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