| DOI | Trouver le DOI : https://doi.org/10.1016/j.jnutbio.2005.05.014 |
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| Auteur | Rechercher : Matchett, Michael D.; Rechercher : MacKinnon, Shawna L.1; Rechercher : Sweeney, Marva I.; Rechercher : Gottschall-Pass, Katherine T.; Rechercher : Hurta, Robert A. R. |
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| Affiliation | - Conseil national de recherches du Canada. Développement des cultures et des ressources aquatiques
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| Format | Texte, Article |
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| Sujet | flavonoids; MMP; PKC; MAP kinase; blueberry; cells |
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| Résumé | Regulation of the matrix metalloproteinases (MMPs) is crucial to regulate extracellular matrix (ECM) proteolysis which is important in metastasis. This study investigated the mechanism(s) by which three flavonoid-enriched fractions from lowbush blueberry (Vaccinium angustifolium) down-regulate MMP activity in DU145 human prostate cancer cells. Metalloproteinase activity was evaluated from cells exposed to “crude,” anthocyanin-enriched (AN) and proanthocyanidin-enriched (PAC) fractions. Differential down-regulation of MMPs was observed. The activity of the endogenous tissue inhibitors of metalloproteinases (TIMPs) from these cells was also evaluated. Increases in TIMP-1 and TIMP-2 activity were observed in response to these fractions. The possible involvement of protein kinase C (PKC) and mitogen-activated protein (MAP) kinase pathways in the flavonoid-mediated decreases in MMP activity was observed. These findings indicate that blueberry flavonoids may use multiple mechanisms in down-regulating MMP activity in these cells. |
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| Date de publication | 2006-02 |
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| Conditions d’utilisation | - Copyright 2006 Elsevier Inc. All rights reserved
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro du CNRC | 1564 |
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| Numéro NPARC | 3538548 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 6fcc3d5a-19bf-4ff8-88ad-8465e9e5551b |
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| Enregistrement créé | 2009-03-01 |
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| Enregistrement modifié | 2020-04-22 |
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