| Téléchargement | - Voir la version finale : Bivalent vaccines effectively protect mice against influenza A and respiratory syncytial viruses (PDF, 2.8 Mio)
- Voir les données supplémentaires : Bivalent vaccines effectively protect mice against influenza A and respiratory syncytial viruses (PPTX, 308 Kio)
|
|---|
| DOI | Trouver le DOI : https://doi.org/10.1080/22221751.2023.2192821 |
|---|
| Auteur | Rechercher : Raman, Sathya N. Thulasi; Rechercher : Zetner, Adrian; Rechercher : Hashem, Anwar M.; Rechercher : Patel, Devina; Rechercher : Wu, Jianguo; Rechercher : Gravel, Caroline; Rechercher : Gao, Jun; Rechercher : Zhang, Wanyue; Rechercher : Pfeifle, Annabelle; Rechercher : Tamming, Levi; Rechercher : Parikh, Karan; Rechercher : Cao, Jingxin; Rechercher : Tam, Roger; Rechercher : Safronetz, David; Rechercher : Chen, Wangxue1; Rechercher : Johnston, Michael J.W.; Rechercher : Wang, Lisheng; Rechercher : Sauve, Simon; Rechercher : Rosu-Myles, Michael; Rechercher : Domselaar, Gary Van; Rechercher : Li, Xuguang |
|---|
| Affiliation | - Conseil national de recherches du Canada. Thérapeutique en santé humaine
|
|---|
| Bailleur de fonds | Rechercher : Health Canada |
|---|
| Format | Texte, Article |
|---|
| Sujet | adenovirus; influenza; RSV; pre-fusion stabilized F; HA-stem; RSV T-cell epitopes |
|---|
| Résumé | Influenza and Respiratory Syncytial virus (RSV) infections together contribute significantly to the burden of acute lower respiratory tract infections. Despite the disease burden, no approved RSV vaccine is available. While approved vaccines are available for influenza, seasonal vaccination is required to maintain protection. In addition to both being respiratory viruses, they follow a common seasonality, which warrants the necessity for a concerted vaccination approach. Here, we designed bivalent vaccines by utilizing highly conserved sequences, targeting both influenza A and RSV, as either a chimeric antigen or individual antigens separated by a ribosome skipping sequence. These vaccines were found to be effective in protecting the animals from challenge by either virus, with mechanisms of protection being substantially interrogated in this communication. |
|---|
| Date de publication | 2023-05-09 |
|---|
| Maison d’édition | Taylor & Francis |
|---|
| Licence | |
|---|
| Dans | |
|---|
| Langue | anglais |
|---|
| Publications évaluées par des pairs | Oui |
|---|
| Exporter la notice | Exporter en format RIS |
|---|
| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
|---|
| Identificateur de l’enregistrement | 73f4c0e8-f401-4ea3-8f73-7c87b1d743a2 |
|---|
| Enregistrement créé | 2024-05-28 |
|---|
| Enregistrement modifié | 2024-05-28 |
|---|
