Antiproliferative activity of the Netherlands propolis and its active principles in cancer cell lines

Par Conseil national de recherches du Canada

DOI	Trouver le DOI : https://doi.org/10.1016/S0378-8741(02)00022-3
Auteur	Rechercher : Banskota, Arjun H.; Rechercher : Nagaoka, Takema; Rechercher : Sumioka, Lucia Yoshie; Rechercher : Tezuka, Yasuhiro; Rechercher : Awale, Suresh; Rechercher : Midorikawa, Kiyoshi; Rechercher : Matsushige, Katsumichi; Rechercher : Kadota, Shigetoshi
Format	Texte, Article
Sujet	Propolis; Antiproliferative activity; DPPH radical scavenging activity; Benzyl caffeate; Phenethyl caffeate; Cinnamyl caffeate
Résumé	The MeOH extract of the Netherlands propolis showed promising antiproliferative activity toward highly liver-metastatic murine colon 26-L5 carcinoma with an EC50 value of 3.5 μg/ml. Further, antiproliferative activity-guided purification of the MeOH extract led us to isolate four flavonoids (1–4), seven cinnamic acid derivatives (5–11) and two new glycerol derivatives (12, 13), whose structures were elucidated on the basis of spectral analysis. The isolated compounds were tested for their antiproliferative activity against murine colon 26-L5, murine B16-BL6 melanoma, human HT-1080 fibrosarcoma and human lung A549 adenocarcinoma cell lines. The benzyl (9), phenethyl (10) and cinnamyl caffeates (11) possessed potent antiproliferative activities with EC50 values of 0.288, 1.76 and 0.114 μM, respectively, toward colon 26-L5 carcinoma. These caffeates were considered to be active constituents of the Netherlands propolis in their antiproliferative activity. The antioxidative activity of these caffeates may play an important role in their antiproliferative activities.
Date de publication	2002-04-01
Dans	Journal of Ethnopharmacology 80, nº 1 (1 avril 2002) : 67–73.
Langue	anglais
Publications évaluées par des pairs	Oui
Publication du CNRC	Cette publication n’est pas du CNRC Ce sont des publications qui ont été rédigées par un auteur du CNRC, mais avant que celui-ci soit employé du CNRC.
Numéro NPARC	21274781
Exporter la notice	Exporter en format RIS
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Identificateur de l’enregistrement	7fb87261-ba85-46f0-9862-e3df2e38faf1
Enregistrement créé	2015-04-08
Enregistrement modifié	2020-03-30

Date de modification :: 2024-07-21