| Téléchargement | - Voir le manuscrit accepté : Silibinin: A novel inhibitor of Aβ aggregation (PDF, 624 Kio)
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| DOI | Trouver le DOI : https://doi.org/10.1016/j.neuint.2010.12.017 |
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| Auteur | Rechercher : Yin, Fei1; Rechercher : Liu, Jianhui1; Rechercher : Ji, Xiuhong1; Rechercher : Wang, Yanwen1; Rechercher : Zidichouski, Jeffrey1; Rechercher : Zhang, Junzeng1 |
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| Affiliation | - Conseil national de recherches du Canada. Institut des sciences nutritionnelles et de la santé du CNRC
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| Format | Texte, Article |
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| Sujet | Aβ aggregation; Neurotoxicity; Silibinin; Thioflavin T (ThT) assay aggregation; Neurotoxicity; Silibinin; Thioflavin T (ThT) assay |
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| Résumé | Alzheimer's disease (AD) is characterized by the abnormal aggregation of amyloid β peptide (Aβ) into extracellular fibrillar deposits known as amyloid plaque. Inhibition of Aβ aggregation is therefore viewed as a potential method to halt or slow the progression of AD. It is reported that silibinin (silybin), a flavonoid derived from the herb milk thistle (Silybum marianum), attenuates cognitive deficits induced by Aβ25-35 peptide and methamphetamine. However, it remains unclear whether silibinin interacts with Aβ peptide directly and decreases Aβ peptide-induced neurotoxicity. In the present study, we identified, through employing a ThT assay and electron microscopic imaging that silibinin also appears to act as a novel inhibitor of Aβ aggregation and this effect showed dose-dependency. We also show that silibinin prevented SH-SY5Y cells from injuries caused by Aβ1-42-induced oxidative stress by decreasing H2O2 production in Aβ1-42-stressed neurons. Taken together, these results indicate that silibinin may be a novel therapeutic agent for the treatment of AD. |
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| Date de publication | 2010-12-17 |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro NPARC | 17364201 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 80200306-166b-42ee-898c-1d0591c00cb9 |
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| Enregistrement créé | 2011-03-22 |
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| Enregistrement modifié | 2020-04-17 |
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