A novel neuron-enriched protein SDIM1 is down regulated in Alzheimer's brains and attenuates cell death induced by DNAJB4 over-expression in neuro-progenitor cells

DOI	Trouver le DOI : https://doi.org/10.1186/1750-1326-6-9
Auteur	Rechercher : Lei, Joy X.¹; Rechercher : Cassone, Cristina G.; Rechercher : Luebbert, Christian; Rechercher : Liu, Qing Y.
Affiliation	Conseil national de recherches du Canada. Institut des sciences biologiques du CNRC
Format	Texte, Article
Résumé	Molecular changes in multiple biological processes contribute to the development of chronic neurodegeneration such as late onset Alzheimer's disease (LOAD). To discover how these changes are reflected at the level of gene expression, we used a subtractive transcription-based amplification of mRNA procedure to identify novel genes that have altered expression levels in the brains of Alzheimer's disease (AD) patients. Among the genes altered in expression level in AD brains was a transcript encoding a novel protein, SDIM1, that contains 146 amino acids, including a typical signal peptide and two transmembrane domains. Here we examined its biochemical properties and putative roles in neuroprotection/neurodegeneration.
Date de publication	2011-01-21
Dans	Molecular Neurodegeneration 6, nº 9 (21 janvier 2011).
Langue	anglais
Publications évaluées par des pairs	Oui
Numéro NPARC	19298568
Exporter la notice	Exporter en format RIS
Signaler une correction	Signaler une correction (s'ouvre dans un nouvel onglet)
Identificateur de l’enregistrement	862c8cc3-abac-4143-8508-c28a670344f7
Enregistrement créé	2012-03-08
Enregistrement modifié	2020-04-21