DOI | Trouver le DOI : https://doi.org/10.3892/ijo.2012.1721 |
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Auteur | Rechercher : Song, Kun; Rechercher : Xu, Peng1; Rechercher : Meng, Yongde1; Rechercher : Geng, Feng; Rechercher : Li, Jie2; Rechercher : Li, Zhao1; Rechercher : Xing, James; Rechercher : Chen, Jie1; Rechercher : Kong, Beihua |
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Affiliation | - Conseil national de recherches du Canada. Technologies de sécurité et de rupture
- Conseil national de recherches du Canada. Thérapeutique en santé humaine
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Format | Texte, Article |
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Sujet | glucose capped gold nanoparticle; radiosensitizing agent; unclassified drug; antineoplastic activity; apoptosis; cancer radiotherapy; cell killing; cellular distribution; comparative study; cytoplasm; drug effect; drug uptake; endocytosis; flow cytometry; human cell; internalization; nick end labeling; radiosensitization; transmission electron microscopy; X irradiation |
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Résumé | The present study explored the cellular uptake dynamics, the subcellular location and the internalization mechanisms of gold nanoparticles (GNPs) and glucose-capped GNPs (Glu-GNPs). The cancer radiotherapy-enhancing effects of GNPs were also evaluated. We synthesized the GNPs and Glu-GNPs by the seeding technique. The effects on cellular uptake and the radiosensitizing effect induced by GNPs and Glu-GNPs at lower doses were investigated using two human cancer cell lines (HeLa and MCF-7). The intracellular location of the nanoparticles was analyzed by transmission electron microscopy (TEM). Analysis of cellular apoptosis following GNP-based radiotherapy was performed by flow cytometry and TUNEL assay. Cancer cells took up more Glu-GNPs than naked GNPs and the uptake curve showed size- and cell-dependent uptake. GNPs were mainly located in the cytoplasm and endocytosis is the mechanism behind the internalization of GNPs and Glu-GNPs. Lower doses of GNPs and Glu-GNPs still enhanced the killing effect using X-ray irradiation, although the apoptotic rate was not altered. The results presented in this study provide evidence that Glu-GNPs may have a bright future in tumor-targeted diagnosis and treatment. |
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Date de publication | 2012-11-29 |
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Dans | |
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Langue | anglais |
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Publications évaluées par des pairs | Oui |
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Numéro NPARC | 21270458 |
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Exporter la notice | Exporter en format RIS |
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Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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Identificateur de l’enregistrement | 9125de9d-04b0-49e1-b9f1-cf62b9b38f90 |
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Enregistrement créé | 2014-02-12 |
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Enregistrement modifié | 2020-04-21 |
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