| Téléchargement | Voir les téléchargements (11) |
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| DOI | Trouver le DOI : https://doi.org/10.1038/s42003-022-03965-x |
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| Auteur | Rechercher : Shao, XiaojianIdentifiant ORCID : https://orcid.org/0000-0002-3044-621X; Rechercher : Vishweswaraiah, SangeethaIdentifiant ORCID : https://orcid.org/0000-0001-5681-5143; Rechercher : Čuperlović-Culf, Miroslava1; Rechercher : Yilmaz, Ali; Rechercher : Greenwood, Celia M. T.Identifiant ORCID : https://orcid.org/0000-0002-2427-5696; Rechercher : Surendra, Anuradha1; Rechercher : McGuinness, Bernadette; Rechercher : Passmore, Peter; Rechercher : Kehoe, Patrick G.Identifiant ORCID : https://orcid.org/0000-0002-7542-1139; Rechercher : Maddens, Michael E.; Rechercher : Bennett, Steffany A. L.; Rechercher : Green, Brian D.; Rechercher : Radhakrishna, UppalaIdentifiant ORCID : https://orcid.org/0000-0002-6617-5634; Rechercher : Graham, Stewart F.Identifiant ORCID : https://orcid.org/0000-0003-1001-0002 |
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| Affiliation | - Conseil national de recherches du Canada. Technologies numériques
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| Format | Texte, Article |
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| Sujet | dementia; epigenetics in the nervous system |
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| Résumé | Dementia with Lewy bodies (DLB) is a common form of dementia with known genetic and environmental interactions. However, the underlying epigenetic mechanisms which reflect these gene-environment interactions are poorly studied. Herein, we measure genome-wide DNA methylation profiles of post-mortem brain tissue (Broadmann area 7) from 15 pathologically confirmed DLB brains and compare them with 16 cognitively normal controls using Illumina MethylationEPIC arrays. We identify 17 significantly differentially methylated CpGs (DMCs) and 17 differentially methylated regions (DMRs) between the groups. The DMCs are mainly located at the CpG islands, promoter and first exon regions. Genes associated with the DMCs are linked to “Parkinson’s disease” and “metabolic pathway”, as well as the diseases of “severe intellectual disability” and “mood disorders”. Overall, our study highlights previously unreported DMCs offering insights into DLB pathogenesis with the possibility that some of these could be used as biomarkers of DLB in the future. |
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| Date de publication | 2022-11-22 |
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| Maison d’édition | Springer Nature |
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| Licence | |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 9268ad9e-e880-4c10-9a8c-26e69b3e8914 |
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| Enregistrement créé | 2023-01-20 |
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| Enregistrement modifié | 2023-01-20 |
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