| Téléchargement | - Voir le manuscrit accepté : Competitive interference between influenza viral strains (PDF, 806 Kio)
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| Auteur | Rechercher : Moghadas, Seyed M.1; Rechercher : Bowman, Christopher S.1; Rechercher : Arino, Julien |
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| Affiliation | - Conseil national de recherches du Canada. Institut du biodiagnostic du CNRC
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| Format | Texte, Article |
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| Sujet | influenza; viral strains; cross-immunity; epidemic models |
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| Résumé | We propose a modelling framework for investigating the dynamics of competition between immunologically-related influenza viral strains in the absence of pre-existing immunity. Assuming that the host immune system will mount partial protection (cross-immunity) against one strain by virtue of having interacted with the other through exposure, we discuss the conditions for the occurrence of two distinct waves of infection during a single epidemic episode. Numerical simulations are presented to illustrate the possibility of infection waves with respect to the protection level induced by the first strain, and the time-lag for evolving the second strain. We propose directions for future work that involves extension of the model to include vaccination. |
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| Date de publication | 2009-07-01 |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro NPARC | 19726585 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 936b9860-8285-4df3-ae4a-8a4558fc244b |
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| Enregistrement créé | 2012-03-28 |
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| Enregistrement modifié | 2020-04-16 |
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