| DOI | Trouver le DOI : https://doi.org/10.1016/j.cbpb.2007.05.006 |
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| Auteur | Rechercher : Roy, Prabir K.1; Rechercher : Lall, Santosh P.2 |
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| Affiliation | - Conseil national de recherches du Canada. Institut des biosciences marines du CNRC
- Conseil national de recherches du Canada. Développement des cultures et des ressources aquatiques
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| Format | Texte, Article |
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| Sujet | Vertebrae; Deformity; Haddock; Histomorphometry; Osteoblasts; Osteoclasts; Mineralization; Vitamin K |
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| Résumé | Vitamin K has been known to regulate bone formation through osteocalcin synthesis by osteoblasts, which is important for mineralization and bone structure. The mechanism underlying the relationship of vitamin K with the changes of microanatomy is not fully understood, and our goal is to test whether bone deformities develop in association with vitamin K deficiency. Fish were fed a semi-purified diet containing either devoid (0.00 mg/kg diet) or adequate (40.0 mg/kg diet supplemented but 20.8 mg/kg analyzed) levels of vitamin K (menadione sodium bisulphite) for 20 weeks. At the end of 8 and 20 weeks, fish were subjected to gross examination and X-ray, and mineral content of the vertebrae was measured. The vertebrae were also subjected to histological, histomorphometric and enzyme histochemical examinations to determine the bone formation and resorption. Vitamin K deficiency primarily decreased bone mineralization and subsequently a decrease in bone mass thus resulted in an increased susceptibility to bone deformity. The occurrence of bone deformities coincided with an increased amount of osteoid tissue and decreased bone mineral content. Number of osteoblasts and osteoclasts were not affected by dietary vitamin K. In conclusion, vitamin K deficiency can impair bone mineralization and enhances bone deformities. |
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| Date de publication | 2007-10 |
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| Conditions d’utilisation | - Copyright © 2007 Elsevier Inc. All rights reserved.
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro du CNRC | 1703 |
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| Numéro NPARC | 3538407 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 94ddaf40-349f-4c48-b4c7-9f673fce351e |
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| Enregistrement créé | 2009-03-01 |
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| Enregistrement modifié | 2020-05-10 |
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