| DOI | Trouver le DOI : https://doi.org/10.1039/c3tb21362e |
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| Auteur | Rechercher : Liu, Shuhan; Rechercher : Ko, Alex C.-T.1; Rechercher : Li, Wenyan; Rechercher : Zhong, Wen; Rechercher : Xing, Malcolm |
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| Affiliation | - Conseil national de recherches du Canada. Dispositifs médicaux
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| Format | Texte, Article |
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| Résumé | In this work, we synthesized a pH sensitive poly(ethylene glycol)-doxorubicin (PEG-DOX) on single-wall carbon nanotubes (SWNTs). Using multimodal nonlinear optical imaging microscopy, we found that low power (1 mW cm-2) near-infrared radiation can initiate prodrug burst release from the carbon nanotubes in seconds. The successful SWNTs capping with PEG-DOX (denoted PEG-DOX@SWNT) was determined by transmission electron microscopy and FTIR results. The in vitro release of DOX from the PEG-DOX@SWNT was evaluated upon changes of pH values and NIR treating time. The cytotoxicity of the PEG-DOX@SWNT was also evaluated. This dual-sensitive delivery system based on SWNTs provides a facile approach to promote drug release and kill cancer cells. |
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| Date de publication | 2014-03 |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro NPARC | 21272775 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 95298f71-c9da-47df-8dd0-a46861557c1b |
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| Enregistrement créé | 2014-12-03 |
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| Enregistrement modifié | 2020-04-22 |
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