| DOI | Trouver le DOI : https://doi.org/10.1111/j.1600-0897.2009.00766.x |
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| Auteur | Rechercher : Krishnan, Lakshmi1; Rechercher : Pejcic-Karapetrovic, Branka; Rechercher : Gurnani, Komal1; Rechercher : Zafer, Ahmed; Rechercher : Sad, Subash1 |
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| Affiliation | - Conseil national de recherches du Canada. Institut des sciences biologiques du CNRC
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| Format | Texte, Article |
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| Sujet | Acquired immunity; CD8 T-cell response; infection; Listeriosis; pregnancy |
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| Résumé | Problem: Listeria monocytogenes (LM) preferentially colonizes the placenta and causes fetal loss and systemic disease during pregnancy. As systemic CD8+ T-cell memory is critical in controlling LM infection, we addressed the issue as to whether it is modulated during pregnancy. Method of study: Pregnant mice were infected with LM and their immune response was quantified relative to the non-pregnant cohort using advanced immunological techniques. Results: Pregnant mice exhibited progressive and massive placental LM infection leading to fetal resorptions. In contrast, they harbored significantly lower bacteria in spleen and liver relative to non-pregnant controls, and rapidly cleared systemic infection. Both pregnant and non-pregnant mice exhibited similar activation of systemic innate immunity. Moreover, LM infection in pregnant and non-pregnant hosts evoked strong antigen-specific cytolytic CD8+ T cells that produced IFN-c. Consequently, LM infection initiated during pregnancy afforded long-term protective memory to secondary infection. Conclusion: Maternal hosts generate a normal Listeria-specific adaptive immunity in particular CD8+ T-cell memory response suggesting that systemic listeriosis during pregnancy may be an immunopathology associated with placental infection. |
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| Date de publication | 2010-01-01 |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro NPARC | 15466239 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 9c8bdd5e-5255-4296-8801-44dda45798a4 |
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| Enregistrement créé | 2010-08-16 |
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| Enregistrement modifié | 2020-04-17 |
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