| DOI | Trouver le DOI : https://doi.org/10.1038/eye.2014.99 |
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| Auteur | Rechercher : Matthews, A.; Rechercher : Hutnik, C.; Rechercher : Hill, K.; Rechercher : Newson, T.; Rechercher : Chan, T.; Rechercher : Campbell, G.1 |
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| Affiliation | - Conseil national de recherches du Canada. Dispositifs médicaux
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| Format | Texte, Article |
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| Sujet | adult; aged; biomechanics; cornea; cornea limbus; corneal strip; drug delivery system; eye; eye indentation; force; ophthalmic needle; sclera |
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| Résumé | PurposeCharacterization of the biomechanical properties of the human eye has a number of potential utilities. One novel purpose is to provide the basis for development of suitable tissue-mimicking material. The purpose of this study was to determine the indentation and needle insertion characteristics on human eye globes and tissue strips.MethodsAn indenter assessed the elastic response of human eye globes and tissue strips under increasing compressive loads. Needle insertion determined the force (N) needed to penetrate various areas of the eye wall.ResultsThe results demonstrated that globes underwent slightly greater indentation at the midline than at the central cornea, and corneal strips indented twofold more than scleral strips, although neither difference was significant (P=0.400 and P=0.100, respectively). Significant differences were observed among various areas of needle insertion (P<0.001). Needle insertion through the anterior sclera (adjacent to the limbus) and posterior sclera (adjacent to the optic nerve) required the greatest amount of force (0.954 and 1.005 N, respectively). The force required to penetrate the central cornea (0.518 N) was significantly lower than all other areas except the midline sclera (0.700 N)ConclusionThese data form the basis for further research into the development of a tissue-mimicking human eye construct with potential utility as a model for use in ophthalmology research and surgical teaching. |
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| Date de publication | 2014-05-09 |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro NPARC | 21272631 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 9e102bdd-bdf1-4f17-b809-ffa78d7aa05a |
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| Enregistrement créé | 2014-12-03 |
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| Enregistrement modifié | 2020-04-22 |
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