The promise and challenges of cyclic dinucleotides as molecular adjuvants for vaccine development

Par Conseil national de recherches du Canada

Téléchargement	Voir la version finale : The promise and challenges of cyclic dinucleotides as molecular adjuvants for vaccine development (PDF, 1.7 Mio)
DOI	Trouver le DOI : https://doi.org/10.3390/vaccines9080917
Auteur	Rechercher : Yan, Hongbin; Rechercher : Chen, Wangxue¹Identifiant ORCID : https://orcid.org/0000-0003-0958-7728
Affiliation	Conseil national de recherches du Canada. Thérapeutique en santé humaine
Bailleur de fonds	Rechercher : Natural Sciences and Engineering Research Council of Canada; Rechercher : National Research Council of Canada
Format	Texte, Article
Description physique	31 p.
Sujet	cyclic dinucleotide; c-di-GMP; bacterial second messenger; immunostimulation; vaccine adjuvant
Résumé	Cyclic dinucleotides (CDNs), originally discovered as bacterial second messengers, play critical roles in bacterial signal transduction, cellular processes, biofilm formation, and virulence. The finding that CDNs can trigger the innate immune response in eukaryotic cells through the stimulator of interferon genes (STING) signalling pathway has prompted the extensive research and development of CDNs as potential immunostimulators and novel molecular adjuvants for induction of systemic and mucosal innate and adaptive immune responses. In this review, we summarize the chemical structure, biosynthesis regulation, and the role of CDNs in enhancing the crosstalk between host innate and adaptive immune responses. We also discuss the strategies to improve the efficient delivery of CDNs and the recent advance and future challenges in the development of CDNs as potential adjuvants in prophylactic vaccines against infectious diseases and in therapeutic vaccines against cancers.
Date de publication	2021-08-17
Maison d’édition	MDPI
Licence	Creative Commons, Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/deed.fr
Dans	Vaccines 9, nº 8, 917 (17 août 2021).
Langue	anglais
Publications évaluées par des pairs	Oui
Exporter la notice	Exporter en format RIS
Signaler une correction	Signaler une correction (s'ouvre dans un nouvel onglet)
Identificateur de l’enregistrement	aa5acc58-9658-4856-afa3-9c5a8090b0f6
Enregistrement créé	2022-11-09
Enregistrement modifié	2023-03-16

Date de modification :: 2024-07-17