Influence of circulating cytokines on prolactin during slow vs. fast exertional heat stress followed by active or passive recovery

Par Conseil national de recherches du Canada

Télécharger	Voir la version finale : Influence of circulating cytokines on prolactin during slow vs. fast exertional heat stress followed by active or passive recovery (PDF, 918 Ko)
DOI	Trouver le DOI : https://doi.org/10.1152/japplphysiol.00523.2012
Auteur	Rechercher : Wright, Heather E.; Rechercher : Mclellan, Tom M.; Rechercher : Friesen, Brian J.; Rechercher : Casa, Douglas J.; Rechercher : Kenny, Glen P.
Format	Texte, Article
Sujet	neuroimmune response; core temperature; peripheral fatigue marker; serotonin and dopamine interplay
Résumé	Prolactin (PRL) has been suggested as an indicator of fatigue during exertional heat stress (EHS), given its strong relationship with body core temperature (Tc); however, the strength of this relationship during different rates of Tc increase and subsequent recovery is unknown. In addition, given the influence that systemic cytokines, such as interleukin (IL)-6 and tumor necrosis factor (TNF)-α, have on the pituitary gland, it would be of interest to determine the relationship between PRL, IL-6, and TNF-α during EHS. The purpose was to examine the PRL, IL-6, and TNF-α heat stress responses during slow and fast heating and subsequent resting or cold water immersion recovery. On 4 days, nine individuals walked at ∼45% (slow heating) or ran at ∼65% (fast heating) maximal oxygen consumption on a treadmill in the heat (40°C, 30% relative humidity) until rectal temperature (Tre) reached 39.5°C (esophageal temperature; fast = 39.41 ± 0.04°C, slow = 39.82 ± 0.09°C). Post-EHS, subjects were either immersed in 2°C water or rested seated until Tre returned to 38.0°C. Venous blood, analyzed for PRL, IL-6, and TNF-α, was obtained at rest, during exercise (Tre 38.0, 39.0, 39.5°C), the start of recovery (∼5 min after 39.5°C), and subsequent recovery (Tre 39.0, 38.0°C). IL-6 exhibited myokine properties, given the greater increases with slow heating and lack of increase in TNF-α. A strong temperature-dependent PRL response during slow and fast heating provides additional support for the use of PRL as a peripheral marker of impending fatigue, which is independent of IL-6 and TNF-α cytokine responses.
Date de publication	2012-08-15
Maison d’édition	American Physical Society
Dans	Journal of Applied Physiology 113, nº 4 : 574–583.
Langue	anglais
Publications évaluées par des pairs	Oui
Publication du CNRC	Cette publication n’est pas du CNRC Ce sont des publications qui ont été rédigées par un auteur du CNRC, mais avant que celui-ci soit employé du CNRC.
Numéro NPARC	23001225
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Identificateur de l’enregistrement	aac8e376-676b-4dcf-b742-1efc65ba60aa
Enregistrement créé	2017-01-06
Enregistrement modifié	2020-06-02

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Date de modification :: 2023-06-07