Identification of a transcript encoding a soluble form of toll-like receptor 5 (TLR5) in Atlantic salmon during Aeromonas salmonicida infection

Par Conseil national de recherches du Canada

Autre titre	Identification of a transcript encoding a soluble form of toll-like receptor 5 (TLR5) in the liver of Atalantic salmon infected with Aeromonas salmonicida
DOI	Trouver le DOI : https://doi.org/10.1016/j.vetimm.2005.05.013
Auteur	Rechercher : Tsoi, Stephen¹; Rechercher : Park, Kyoung C.¹; Rechercher : Kay, Helen H.; Rechercher : O'Brien, Timothy J.; Rechercher : Eszter, Podor; Rechercher : Sun, Genlou; Rechercher : Douglas, Susan E.¹; Rechercher : Brown, Laura L.¹; Rechercher : Johnson, Stewart C.¹
Affiliation	Conseil national de recherches du Canada. Institut des biosciences marines du CNRC
Format	Texte, Article
Sujet	soluble toll-like receptor; leucine-rich-repeats; LRR; inflammation; Atlantic salmon
Résumé	Toll-like receptors (TLRs) are involved in the innate immune response against microbial pathogens in vertebrates and insects. The extracellular region of a TLR recognizes pathogen-associated molecules, while the intracellular region initiates the signaling pathway leading to immune response. Membrane-bound TLRs have been found in most vertebrates, but few soluble forms have been reported. A novel transcript corresponding to a portion of a soluble TLR was identified in liver of infected Atlantic salmon. The complete coding sequence of this TLR was obtained and BLASTN analysis showed the highest sequence identity to a recently described full-length cDNA sequence of a soluble TLR5 from rainbow trout (GenBank Accession No.: AB062504). The deduced protein is 40% identical to the mammalian counterpart of the leucine-rich repeat (LRR)/LRR-like motifs of TLR5. Based on the structure of human TLRs, it contains 21 LRRs with conserved LxxLxLxxNxxxxxxxFxxL pattern. Since TLR5 is essential for the recognition of bacterial flagellins, we hypothesize that flagellin and perhaps some other pathogen-derived factors from Aeromonas salmonicida bind to this soluble TLR through an unknown binding domain within the LRR.
Date de publication	2006-01-01
Conditions d’utilisation	Copyright © 2005 Elsevier B.V. All rights reserved.
Dans	Veterinary Immunology and Immunopathology 109, nº 1-2 (1 janvier 2006) : 183–187.
Langue	anglais
Publications évaluées par des pairs	Oui
Numéro du CNRC	NRCC 55506 1641
Numéro NPARC	3538328
Exporter la notice	Exporter en format RIS
Signaler une correction	Signaler une correction (s'ouvre dans un nouvel onglet)
Identificateur de l’enregistrement	ac471292-ff11-41c9-b867-e8310357ac41
Enregistrement créé	2009-03-01
Enregistrement modifié	2020-04-22

Date de modification :: 2024-06-30