| Téléchargement | - Voir le manuscrit accepté : Label-free imaging of arterial tissues using photonic crystal fibre (PCF) based nonlinear optical microscopic system (PDF, 865 Kio)
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| DOI | Trouver le DOI : https://doi.org/10.1117/12.809361 |
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| Auteur | Rechercher : Ko, Alex C. T.1; Rechercher : Ridsdale, Andrew2; Rechercher : Pegoraro, Adrian F.2; Rechercher : Smith, Michael S. D.1; Rechercher : Mostaço-Guidolin, Leila B.; Rechercher : Hewko, Mark D.1; Rechercher : Kohlenberg, Elicia M.1; Rechercher : Schattka, Bernie J.1; Rechercher : Shiomi, Masashi; Rechercher : Stolow, Albert2; Rechercher : Sowa, Michael G.1 |
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| Affiliation | - Conseil national de recherches du Canada. Institut du biodiagnostic du CNRC
- Conseil national de recherches du Canada. Institut Steacie des sciences moléculaires du CNRC
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| Format | Texte, Article |
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| Conférence | Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues VII, 26 January 2009, San Jose, CA, USA |
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| Sujet | Nonlinear optical microscopy; photonic crystal fibre; coherent anti-Stokes Raman scattering; two photon excited fluorescence; second harmonic generation; Atherosclerosis |
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| Résumé | Nonlinear optical (NLO) microscopy provides a minimally invasive optical method for fast molecular imaging at subcellular resolution with 3D sectioning capability in thick, highly scattering biological tissues. In the current study, we demonstrate the imaging of arterial tissue using a nonlinear optical microscope based on photonic crystal fiber and a single femto-second oscillator operating at 800nm. This NLO microscope system is capable of simultaneous imaging extracellular elastin/collagen structures and lipid distribution within aortic tissue obtained from coronary atherosclerosis-prone WHHLMI rabbits (Watanabe heritable hyperlipidemic rabbit-myocardial infarction) Clear pathological differences in arterial lumen surface were observed between healthy arterial tissue and atherosclerotic lesions through NLO imaging. |
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| Date de publication | 2009-02-01 |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro NPARC | 19697993 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | bb462be8-6197-47c9-af3e-09cc07c8a5b3 |
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| Enregistrement créé | 2012-03-22 |
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| Enregistrement modifié | 2020-04-16 |
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