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Web-based inference of biological patterns, functions and pathways from metabolomic data using MetaboAnalyst

Par Conseil national de recherches du Canada

DOITrouver le DOI : https://doi.org/10.1038/nprot.2011.319
AuteurRechercher : ; Rechercher : 1
Affiliation
  1. Conseil national de recherches du Canada. Institut national de nanotechnologie
FormatTexte, Article
Sujetbiology; computer program; information processing; metabolite; metabolomics; multivariate analysis; univariate analysis; web browser; Data Interpretation, Statistical; Internet; Metabolic Networks and Pathways; Metabolomics; Models, Biological; Multivariate Analysis; Software
Résumé
MetaboAnalyst is an integrated web-based platform for comprehensive analysis of quantitative metabolomic data. It is designed to be used by biologists (with little or no background in statistics) to perform a variety of complex metabolomic data analysis tasks. These include data processing, data normalization, statistical analysis and high-level functional interpretation. This protocol provides a step-wise description on how to format and upload data to MetaboAnalyst, how to process and normalize data, how to identify significant features and patterns through univariate and multivariate statistical methods and, finally, how to use metabolite set enrichment analysis and metabolic pathway analysis to help elucidate possible biological mechanisms. The complete protocol can be executed in ∼45 min. © 2011 Nature America, Inc. All rights reserved.
Date de publication
Dans
  • Nature Protocols 6, nº 6 (2011) : 743–760.
Langueanglais
Publications évaluées par des pairsOui
Numéro NPARC21271284
Exporter la noticeExporter en format RIS
Signaler une correctionSignaler une correction (s'ouvre dans un nouvel onglet)
Identificateur de l’enregistrementbf22bcec-afb3-4a14-8c1a-8d3137665d35
Enregistrement créé2014-03-24
Enregistrement modifié2020-04-21
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