Isolation of 41a-Homoyessotoxin and the Identification of 9-Methyl-41a-homoyessotoxin and Nor-ring A-yessotoxin from Protoceratium reticulatum

Par Conseil national de recherches du Canada

DOI	Trouver le DOI : https://doi.org/10.1021/tx049832r
Auteur	Rechercher : Miles, Christopher O.; Rechercher : Wilkins, Alistair L.; Rechercher : Jensen, Dwayne J.; Rechercher : Cooney, Janine M.; Rechercher : Quilliam, Michael A.¹; Rechercher : Aasen, John; Rechercher : MacKenzie, A. Lincoln.
Affiliation	Conseil national de recherches du Canada. Science des mesures et étalons
Format	Texte, Article
Sujet	toxins; Protoceratium reticulatum; NMR; mass spectrometry
Résumé	41a-Homoyessotoxin (1), a new analogue of yessotoxin (7), was isolated from extracts of Protoceratium reticulatum grown in culture. In addition, 9-methyl-41a-homoyessotoxin (2) and a nor-ring A-yessotoxin (3) were identified as the major components of a mixed fraction. The structural information was initially obtained from LC-UV and LC-MS3 chromatograms, with subsequent definitive structure determination by NMR, LC-MS/MS, and high-resolution MS. Full 1H and indirectly detected 13C NMR assignments for all but two carbon atoms were obtained from ca. 100 μg of 1. Full 1H NMR assignments for 2 and 3 and identification of three new heptanor-41-oxo-analogues of 3 (4−6) during LC-MS3 analysis of a fraction containing 1−3 and 7 are also reported.
Date de publication	2004-10-15
Conditions d’utilisation	© 2004 American Chemical Society
Dans	Chemical Research in Toxicology 17, nº 11 (15 octobre 2004) : 1414–1422.
Langue	anglais
Publications évaluées par des pairs	Oui
Numéro du CNRC	1694
Numéro NPARC	3538185
Exporter la notice	Exporter en format RIS
Signaler une correction	Signaler une correction (s'ouvre dans un nouvel onglet)
Identificateur de l’enregistrement	c2dfbec9-56c8-4cf8-b631-caeb70160392
Enregistrement créé	2009-03-01
Enregistrement modifié	2020-04-17

Date de modification :: 2024-04-19