DOI | Trouver le DOI : https://doi.org/10.1016/j.bbrc.2009.07.061 |
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Auteur | Rechercher : Yan, Hongbin; Rechercher : KuoLee, Rhonda1; Rechercher : Tram, Kha; Rechercher : Qiu, Hongyu1; Rechercher : Zhang, Jianbing1; Rechercher : Patel, Girishchandra B.1; Rechercher : Chen, Wangxue1 |
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Affiliation | - Conseil national de recherches du Canada. Institut des sciences biologiques du CNRC
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Format | Texte, Article |
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Sujet | cdiGMP; Mucosal adjuvant; Immunostimulation; Immunization; antibody |
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Résumé | 3',5'-Cyclic diguanylic acid (cdiGMP) is emerging as a universal bacterial second messenger in regulating bacterial growth on surfaces. It has been recently shown that cdiGMP stimulates innate immunity and enhances antigen-specific humoral and cellular immune responses. We herein report that intranasal (i.n.) administration with cdiGMP induces an acute but transient inflammatory response and activation of dendritic cells in the lungs. Moreover, i.n. immunization of mice with pneumococcal surface adhesion A (PsaA) in conjunction with cdiGMP elicited strong antigen-specific serum immunoglobulin G (IgG) and secretory IgA antibody responses at multiple mucosal surfaces. More importantly, the immunized mice showed significantly reduced nasopharyngeal Streptococcus pneumoniae colonization. These results, for the first time, provide direct evidence for the induction of protection against mucosal bacterial infections by cdiGMP as an adjuvant. |
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Date de publication | 2009-07-16 |
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Dans | |
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Langue | anglais |
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Publications évaluées par des pairs | Oui |
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Numéro NPARC | 15329267 |
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Exporter la notice | Exporter en format RIS |
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Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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Identificateur de l’enregistrement | c316df2a-3980-4d80-8343-25611a541b27 |
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Enregistrement créé | 2010-05-21 |
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Enregistrement modifié | 2020-04-16 |
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