| DOI | Trouver le DOI : https://doi.org/10.3109/17435390.2014.948941 |
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| Auteur | Rechercher : Rocheleau, Sylvie1; Rechercher : Arbour, Mélanie1; Rechercher : Elias, Miria2; Rechercher : Sunahara, Geoffrey I.3; Rechercher : Masson, Luke1 |
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| Affiliation du nom | - Conseil national de recherches du Canada. Thérapeutique en santé humaine
- Conseil national de recherches du Canada. Énergie, les mines et l'environnement
- Conseil national de recherches du Canada. Développement des cultures et des ressources aquatiques
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| Format | Texte, Article |
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| Sujet | Gene expression; juglone; nanoparticles; oxidative stress; titanium dioxide |
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| Résumé | The toxicity and toxicogenomics of selected anatase and rutile nanoparticles (NP) and bulk titanium dioxide (TiO2) particles were evaluated in the soil nematode Caenorhabditis elegans. Results indicated that bulk or nano-TiO2 particles were slightly toxic to soil nematode C. elegans, as measured by reproduction EC50 values ranging from 4 to 32 mg/L. Whole-genome microarray results indicated that the regulation of glutathione-S-transferase gst-3, cytochrome P450 cypp33-c11, stress resistance regulator scl-1, oxidoreductase wah-1 and embryonic development pod-2 genes were significantly affected by nano-sized and bulk-TiO2 particles. More specifically, it was determined that anatase particles exerted a greater effect on metabolic pathways, whereas rutile particles had a greater effect on developmental processes. The up-regulation of the pod-2 gene corroborated the phenotypic effect observed in the reproduction test. Our results demonstrated that C. elegans is a good genomic model for nano-TiO2 toxicity assessment. |
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| Date de publication | 2015-05 |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro du CNRC | NRCC 55498 |
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| Numéro NPARC | 21275438 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | c69cf2ac-cd6d-4830-93b3-47e1c87f18dd |
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| Enregistrement créé | 2015-07-13 |
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| Enregistrement modifié | 2020-04-22 |
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