| DOI | Trouver le DOI : https://doi.org/10.1016/j.carbpol.2022.120108 |
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| Auteur | Rechercher : Hrapovic, Sabahudin1; Rechercher : Martinez-Farina, Camilo F.1; Rechercher : Sui, Jessie; Rechercher : Lavertu, Jean-Danick1; Rechercher : Hemraz, Usha D.1 |
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| Affiliation | - Conseil national de recherches du Canada. Développement des cultures et des ressources aquatiques
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| Bailleur de fonds | Rechercher : National Research Council of Canada |
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| Format | Texte, Article |
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| Sujet | chitosan nanocrystals; amino acids; peptides; nanomaterials; solid phase synthesis |
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| Résumé | Antimicrobial peptides (AMPs) offer a great promise in designing new therapeutics due to their ability to interfere in bacterial growth by penetrating the cell wall. The overuse of antibiotics has resulted into antibiotic-resistant bacteria and AMPs could be an alternative to circumvent this resistance. Chitosan nanocrystals (ChsNCs) are rod-shaped polysaccharide-based nanomaterials, formed by deacetylation of seafood waste. They possess primary amino groups on the surface of the nanoparticles which can be as used a scaffold due to the built-in morphology and ease in functionalization. Here, we developed a new methodology to functionalize ChsNCs with amino acids and peptides by using fundamentals of solid phase peptide synthesis. The resulting functionalized rod-shaped nanomaterials were characterized using nuclear magnetic resonance (NMR), dynamic light scattering (DLS), zeta potential measurements and microscopy imaging. This synthetic strategy could be used in designing ChsNC-based nanomaterials to target specific cells by attaching bioactive peptides to the nanomaterial surface. |
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| Date de publication | 2022-09-15 |
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| Maison d’édition | Elsevier |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Identificateur | S014486172201013X |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | c86fdfb3-bedc-4328-af49-c2bd5ca7b023 |
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| Enregistrement créé | 2022-12-02 |
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| Enregistrement modifié | 2023-03-16 |
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