| DOI | Trouver le DOI : https://doi.org/10.1016/S0028-3908(96)00158-X |
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| Auteur | Rechercher : Ligenhöhl, K.; Rechercher : Small, D. L.1; Rechercher : Monette, R.1; Rechercher : Buchan, A. M.; Rechercher : Morley, P.1; Rechercher : Allegrini, P. R.; Rechercher : Fröstl, W.; Rechercher : Sauer, D.; Rechercher : Schmutz, M.; Rechercher : Knöpfel, T. |
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| Affiliation | - Conseil national de recherches du Canada. Institut des sciences biologiques du CNRC
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| Format | Texte, Article |
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| Résumé | We investigated the neuroprotective efficacy of the P-type Ca2+ channel antagonist daurisoline against electroshock-induced convulsions in rats and mice, hypoxic/hypoglycemic-induced damage in rat hippocampal slices and brain damage induced by occlusion of the middle cerebral artery (MCA) in rats. Daurisoline applied intravenously (i.v.) (bolus of 1–60 mg/kg) reduced the spontaneous activity of rat cerebellar Purkinje cells in a dose-dependent manner, a result demonstrating activity in the brain with systemic administration of the compound. While this effect reversed rapidly in about 10–20 min following bolus-application of the drug at doses of up to 30 mg/kg, a dose of 60 mg/kg consistently induced a depression of respiration followed by death of the animals. Daurisoline administered at 10–30 mg/kg did not prevent electroshock-induced convulsions in mice or rats, nor did it reduce neuronal damage in hippocampal slices induced by a hypoxic/hypoglycemic insult in vitro or by MCA occlusion in vivo. These observations do not support the hypothesis that P-type Ca2+ channels are promising drug targets for the acute treatment of epileptic convulsions and/or ischemic stroke. |
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| Date de publication | 1997 |
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| Dans | |
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| Langue | anglais |
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| Numéro du CNRC | LIGENHOHL1997 |
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| Numéro NPARC | 9363309 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | cdcbb0c0-6270-48c4-93db-0b8851c811dd |
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| Enregistrement créé | 2009-07-10 |
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| Enregistrement modifié | 2020-03-20 |
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