| Téléchargement | - Voir la version finale : A new approach for manufacturing and processing targets to produce 99mTc with cyclotrons (PDF, 754 Kio)
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| DOI | Trouver le DOI : https://doi.org/10.1142/S0217732317400119 |
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| Auteur | Rechercher : Matei, L.; Rechercher : Mcrae, G.; Rechercher : Galea, R.1; Rechercher : Niculae, D.; Rechercher : Craciun, L.; Rechercher : Leonte, R.; Rechercher : Surette, G.; Rechercher : Langille, S.; Rechercher : Louis, C. St.; Rechercher : Gelbart, W.; Rechercher : Abeysekera, B.; Rechercher : Johnson, R. R. |
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| Affiliation | - Conseil national de recherches du Canada. Science des mesures et étalons
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| Format | Texte, Article |
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| Sujet | 99mTc; cyclotron; target; target processing |
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| Résumé | The most important radioisotope for nuclear medicine is 99mTc. After the supply crisis of 99Mo starting in 2008, the availability of 99mTc became a worldwide concern. Alternative methods for producing the medical imaging isotope 99m 99mTc are actively being developed around the world. The reaction 100 100Mo(p, 2n) 99mTc provides a direct route that can be incorporated into routine production in nuclear medicine centers that possess medical cyclotrons for production of other isotopes, such as those used for Positron Emission Tomography. This paper describes a new approach for manufacturing targets for the (p, 2n) nuclear reaction on 100Mo and the foundation for the subsequent commercial separation and purification of the 99mTc produced. Two designs of targets are presented. The targets used to produce 99mTc are subject to a number of operational constraints.They must withstand the temperatures generated by the irradiation, accommodate temperature gradients from cooling system of the target, must be resilient and must be easily post-processed to separate the 99mTc. After irradiation, the separation of Tc from Mo was carried out using an innovative two-step approach. The process described in this paper can be automated with modules that easily fit in standard production hot cells found in nuclear medicine facilities. |
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| Date de publication | 2017-05-08 |
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| Maison d’édition | World Scientific Publishing |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro NPARC | 23002356 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | d701bd8f-9420-441b-a47d-fa15f6876c5d |
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| Enregistrement créé | 2017-10-23 |
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| Enregistrement modifié | 2020-05-30 |
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