Structural and immunochemical characterization of the type VIII group B Streptococcus capsular polysaccharide

Par Conseil national de recherches du Canada

Auteur	Rechercher : Kogan, G.; Rechercher : Uhrin, D.; Rechercher : Brisson, J.; Rechercher : Paoletti, L.; Rechercher : Blodgett, A.; Rechercher : Kasper, D.; Rechercher : Jennings, Harold
Format	Texte, Article
Sujet	13C-NMR; 1H-NMR; acids; antigens; antigens, bacterial; bacterial; bacterial capsules; Canada; capsular polysaccharide; capsule; carbohydrate sequence; chemistry; d-glucose; group B Streptococcus; high-resolution; immunochemical characterization; immunology; magnetic resonance spectroscopy; Meningitis; molar; molecular sequence data; Neuraminidase; NMR spectroscopy; nuclear magnetic resonance; oxidation-reduction; polysaccharides; repeating unit; resolution; resonance; sialic acids; strains; Streptococcus; Streptococcus agalactiae; structural; structure; support, U.S. Gov't, P.H.S.; unit
Résumé	The type VIII capsular polysaccharide has been isolated and purified from a newly described strain of group B Streptococcus which is a leading cause of sepsis and neonatal meningitis in Japan. The polysaccharide contains D-glucose, D-galactose, L-rhamnose, and sialic acid in the molar ratio 1:1:1:1. By means of high resolution 1H nuclear magnetic resonance (1H NMR), 13C NMR, and homo- and heterocorrelated NMR, the repeating unit structure of the type VIII polysaccharide was delineated as the following, [formula: see text] Enzymatic studies established this polysaccharide as the first from which sialic acid, linked to a branched beta-D-galactopyranosyl residue, is known to be removed by bacterial neuraminidase
Date de publication	1996-04-12
Maison d’édition	American Society for Biochemistry and Molecular Biology
Dans	The Journal of Biological Chemistry 271, nº 15 : 8786–8790.
Langue	anglais
Publications évaluées par des pairs	Oui
Numéro du CNRC	KOGAN1996
Numéro NPARC	9364359
Exporter la notice	Exporter en format RIS
Signaler une correction	Signaler une correction (s'ouvre dans un nouvel onglet)
Identificateur de l’enregistrement	d70dd315-1daf-4e1a-ae56-d58768d6b8ba
Enregistrement créé	2009-07-10
Enregistrement modifié	2020-03-20

Date de modification :: 2024-07-01