| Téléchargement | - Voir le manuscrit accepté : Tracking cognitive changes in new-onset epilepsy : functional imaging challenges (PDF, 5.4 Mio)
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| DOI | Trouver le DOI : https://doi.org/10.1111/j.1528-1167.2011.03152.x |
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| Auteur | Rechercher : D'Arcy, Ryan C. N.1; Rechercher : Gawryluk, Jodie R.1; Rechercher : Beyea, Steven D.1; Rechercher : Ghosh Hajra, Sujoy1; Rechercher : Feindel, Kirk W.1; Rechercher : Clarke, David B. |
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| Affiliation | - Conseil national de recherches du Canada. Institut du biodiagnostic du CNRC
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| Format | Texte, Article |
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| Sujet | new onset epilepsy; temporal lobe epilepsy; functional magnetic resonance imaging; electroencephalography; event-related brain potentials; magnetoencephalography; memory; cognition |
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| Résumé | Functional imaging has potential for tracking changes in cognition during the onset and evolution of epilepsy. Although the concept of imaging such changes over time is an exciting new direction, feasibility remains an open question. The current article outlines a case example in which functional magnetic resonance imaging (fMRI) and event-related potentials (ERPs) were used to monitor memory changes before and after selective temporal lobe resection. From this example, three key methodologic challenges for new-onset epilepsy are identified and discussed. The first challenge relates to the interpretation of results in regions near epileptogenic tissue. We argue that this is best addressed by collecting information from multiple modalities to test for convergent evidence. The second challenge relates to optimizing the methods for sensitivity to detecting changes. In this case, enhanced imaging methods and a region-of-interest approach provide necessary focus. The third and final challenge relates to the practical difficulties of conducting research in new-onset epilepsy cases. We suggest that greater integration of imaging research within the clinical setting is needed. |
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| Date de publication | 2011-07 |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro NPARC | 19688668 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | e5611d62-3f4b-4397-b18f-8c01274c0134 |
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| Enregistrement créé | 2012-03-22 |
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| Enregistrement modifié | 2020-04-21 |
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