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Simon metabolites of α-tocopherol are not formed via a rate-controlling scission of the 3′C-H bond

Par Conseil national de recherches du Canada

DOITrouver le DOI : https://doi.org/10.1016/0891-5849(90)90021-A
AuteurRechercher : 1; Rechercher : 2; Rechercher : 1; Rechercher : 1
Affiliation
  1. Conseil national de recherches Canada. Institut Steacie des sciences moléculaires du CNRC
  2. Conseil national de recherches Canada
FormatTexte, Article
Sujetalpha tocopherol; deuterium; adrenal gland; animal tissue; brain cortex; drug metabolism; gas chromatography; isotope labeling; kidney; liver; male; mass spectrometry; oral drug administration; rat; free radicals; kinetics; male; oxidation-reduction; rats; rats, inbred strains; support, Non-U.S. Gov't; vitamin E; animalia
Résumé
The major in vivo oxidation products of α-tocopherol, α-T, are the Simon metabolites, 1 and 2. For these compounds to be formed from α-T the polyisoprenoid tail of α-T must be oxidatively cleaved at the 3′ carbon atom. Comparison of the levels of 2R,4′R,8′R-α-(3′,3′-2H2)-T and 2R,4′R,8′R-α-[5,7-(C2H3)2-T remaining in various tissues of rats which had been preloaded with equal quantities of these two forms of vitamin E following a change to a vitamin E-free diet has shown that there is no statistically significant difference in the rates of loss of these two deuterium-labeled α-T's. This demonstrates that the Simon metabolites are not formed by a rate-controlling scission of the 3′-C-H bond of α-T. © 1990.
Date de publication
Dans
  • Free Radical Biology and Medicine 9, nº 5 (1990) : 435–439.
Langueanglais
Publications évaluées par des pairsOui
Numéro NPARC21276787
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Identificateur de l’enregistremente7465945-ae39-49c5-98fd-e1f4230a3300
Enregistrement créé2015-10-13
Enregistrement modifié2020-03-17
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