| Téléchargement | - Voir le manuscrit accepté : Study of chronic lymphocytic leukemia cells by FT-IR spectroscopy and cluster analysis (PDF, 1.4 Mio)
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| DOI | Trouver le DOI : https://doi.org/10.1016/0145-2126(96)00019-7 |
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| Auteur | Rechercher : Schultz, Christian P.1; Rechercher : Liu, Kan-Zhi1; Rechercher : Johnston, James B.; Rechercher : Mantsch, Henry H.1 |
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| Affiliation | - Conseil national de recherches du Canada. Institut du biodiagnostic du CNRC
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| Format | Texte, Article |
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| Sujet | FT-IR spectroscopy; chronic lymphocytic leukemia; cluster analysis; B-Lymphocyte; Fourier spectrometry; lipids; proteins; chronic; malignant hemopathy; leucémie lymphoïde; spectrométrie de FT-IR; analyse amas; lymphocyte B; spectrométrie Fourier; lipide; protéine; chronique; hémopathie maligne; Syndrome lymphoprolifératif |
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| Résumé | The peripheral mononuclear cells from 23 normal individuals and the purified B cells from 38 patients with chronic lymphocytic leukemia (CLL) were examined by Fourier transform infrared (FT-IR) spectroscopy. Differences were observed between the CLL and normal cells at the DMA, protein and lipid levels, with CLL cells having greater DNA and lower lipid contents than normal cells. In addition, the spectral character of the CLL and normal cells varied, demonstrating that there were also qualitative differences in the DNA and lipids. Statistical analysis, based on hierarchical clustering, separated normal from CLL cells completely and classified them into two subgroups for normal cells, while the CLL cells could be divided into three subgroups that were distinct from the normal cells. These differences were based on the lipid and DNA content and the overall spectral character of the cells. |
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| Date de publication | 1996-08 |
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| Conditions d’utilisation | - You may reproduce (print, make photocopies, or download) the accepted manuscript without permission for non-commercial purposes (research, education, and private study), on the condition that you provide proper attribution of the source in all copies.
- Vous pouvez reproduire (imprimer, faire des photocopies ou télécharger) le manuscrit accepté sans autorisation à des fins non commerciales (recherche, éducation et études privées), à condition de fournir la source appropriée dans toutes les copies.
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| Condition d’accès | |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro du CNRC | 415 |
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| Numéro NPARC | 9201851 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | ed05b69f-f63c-4e6a-a077-25b97a2781e5 |
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| Enregistrement créé | 2009-10-02 |
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| Enregistrement modifié | 2020-03-20 |
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