| DOI | Trouver le DOI : https://doi.org/10.1021/bi00461a016 |
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| Auteur | Rechercher : Hauser, Helmut; Rechercher : Mantsch, Henry H.1; Rechercher : Casal, Hector L.1 |
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| Affiliation du nom | - Conseil national de recherches du Canada
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| Format | Texte, Article |
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| Résumé | ³¹P NMR and infrared spectroscopic methods have been used to study the formation of small unilamellar vesicles by the pH-jump method. It is shown that increasing the pH of different lamellar phospholipid dispersions (phosphatidic acids and phosphatidylserines) induces a pH gradient. This pH gradient is estimated to be 4 ± 1 pH units, and its direction is such that the inner monolayer of the vesicles is at lower pH. There is spectroscopic evidence for tighter packing of the lipid hydrocarbon chains in the inner monolayer, probably due to the constraints imposed by the high curavture of the small vesicles formed. There results are discussed in terms of the driving force of the spontaneous vesiculation. |
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| Date de publication | 1990-03 |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro du CNRC | NRCC 30762 |
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| Numéro NPARC | 23001506 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | efc4bae8-f526-4069-a800-3ce19453f4c1 |
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| Enregistrement créé | 2017-02-20 |
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| Enregistrement modifié | 2020-03-17 |
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