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Constitutive Modelling of Endothelium Denudation for Finite Element Simulation of Angioplasty

Par Conseil national de recherches du Canada

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DOITrouver le DOI : https://doi.org/10.1007/978-3-540-70521-5_3
AuteurRechercher : 1; Rechercher : 1; Rechercher : 1
Affiliation
  1. Conseil national de recherches du Canada. Institut des matériaux industriels du CNRC
FormatTexte, Article
ConférenceInternational Symposium on Computational Models for Biomedical Simulation - ISBMS08, London, UK, July 7-8, 2008
Sujetangioplasty; restenosis; endothelium; stretch; friction; pressure
Résumé
This study aims at characterizing and modelling the effect of mechanical factors on endothelial denudation during angioplasty, such as normal force between balloon and artery, stretching of arterial walls, and relative displacement between contacting surfaces. Friction damage was applied to porcine aorta samples with different contact forces, relative displacements, and biplanar stretching conditions. After the tests, endothelium denudation was quantified by isolating and counting the remaining endothelial cells. Using multiple-regression analysis, a constitutive model is proposed for integration in finite element software. This model will help optimize balloon and stent deployment conditions to minimize the amount of damage to the endothelium, and eventually to reduce the occurrence of restenosis.
Date de publication
Dans
  • Biomedical Simulation. 4th International Symposium, ISBMS 2008, London, UK, July 7-8, 2008. Proceedings (2008) : 19–27.
  • Lecture notes in Computer Science 5104.
Langueanglais
Publications évaluées par des pairsOui
Numéro du CNRCNRCC 50250
NRCC 52324
Numéro NPARC18890171
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Identificateur de l’enregistrementf00fb9f1-6698-4454-942d-5fd81dd312f9
Enregistrement créé2011-11-04
Enregistrement modifié2020-04-15
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