| Téléchargement | - Voir le manuscrit accepté : Baicalin prevents the production of hydrogen peroxide and oxidative stress induced by Abeta aggregation in SH-SY5Y cells (PDF, 613 Kio)
|
|---|
| DOI | Trouver le DOI : https://doi.org/10.1016/j.neulet.2011.01.055 |
|---|
| Auteur | Rechercher : Yin, Fei1; Rechercher : Liu, Jianhui1; Rechercher : Ji, Xiuhong1; Rechercher : Wang, Yanwen1; Rechercher : Zidichouski, Jeffrey1; Rechercher : Zhang, Junzeng1 |
|---|
| Affiliation | - Conseil national de recherches du Canada. Institut des sciences nutritionnelles et de la santé du CNRC
|
|---|
| Format | Texte, Article |
|---|
| Sujet | baicalin; copper; Abeta; aggregation; hydrogen peroxide |
|---|
| Résumé | Alzheimer’s disease (AD) is a common form of neurodegenerative disease. Mounting evidence suggests that metal ions play a key role in the aggregation of amyloid β peptide (Aβ), which acts as a factor or cofactor in the etiopathogenesis of AD. Therefore, inhibition of Aβ aggregation emerges as a potential approach for the treatment of AD. We have found that baicalin can interact with copper directly and inhibits Aβ 1–42 aggregation. In addition, baicalin protects SH-SY5Y cells from oxidative injuries induced by Aβ 1–42 aggregation through decreasing H2O2 production that is normally formed as a deleterious byproduct of beta amyloid aggregation and the formation of plaques. Taken together, these data indicate that baicalin may be a potential agent to inhibit Aβ aggregation and thereby delay, mitigate or modify the progression of neurodegenerative diseases such as AD. |
|---|
| Date de publication | 2011-01-21 |
|---|
| Dans | |
|---|
| Langue | anglais |
|---|
| Publications évaluées par des pairs | Oui |
|---|
| Numéro NPARC | 17364189 |
|---|
| Exporter la notice | Exporter en format RIS |
|---|
| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
|---|
| Identificateur de l’enregistrement | f0955e6b-d4f3-439b-b385-ff7423ac411c |
|---|
| Enregistrement créé | 2011-03-22 |
|---|
| Enregistrement modifié | 2020-04-21 |
|---|
