| DOI | Trouver le DOI : https://doi.org/10.1016/j.carres.2009.08.028 |
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| Auteur | Rechercher : Zou, Wei1; Rechercher : Vembaiyan, Kannan1; Rechercher : Bhasin, Milan1; Rechercher : Williams, Dean T.1 |
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| Affiliation | - Conseil national de recherches du Canada. Institut des sciences biologiques du CNRC
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| Format | Texte, Article |
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| Sujet | Synthesis; Morphan; Tandem reaction; C-Glycoside |
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| Résumé | Highly functionalized morphan derivatives were synthesized from nitroalkene 2'-(oxoalkyl)-C-glycosides by a tandem reaction that created three (two C–N and one C–C) new bonds and four stereogenic centers in a one-pot procedure under very mild conditions without the use of expensive reagents. The transformation was achieved from a β-elimination/Michael addition cascade, followed by Michael addition of the amine and intramolecular enamination. In the presence of sodium cyanoborohydride the iminium intermediate was reduced in situ to afford the desired morphans. |
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| Date de publication | 2009-08-27 |
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| Dans | |
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| Langue | anglais |
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| Numéro NPARC | 15329245 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | f0a0c5b9-ffee-4abc-83df-2f6969d02105 |
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| Enregistrement créé | 2010-05-21 |
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| Enregistrement modifié | 2020-04-16 |
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