| DOI | Trouver le DOI : https://doi.org/10.1186/1472-6831-14-25 |
|---|
| Auteur | Rechercher : Zhang, C.; Rechercher : Xiang, X.1; Rechercher : Xu, M.1; Rechercher : Fan, C.; Rechercher : Sowa, M.G.1; Rechercher : Liu, K.-Z.1 |
|---|
| Affiliation | - Conseil national de recherches du Canada. Dispositifs médicaux
|
|---|
| Format | Texte, Article |
|---|
| Résumé | Background: We have recently developed a non-invasive periodontal diagnostic tool that was validated in periodontitis patients without systemic disorders like coronary artery disease (CAD). The purpose of present study is to verify whether this optical instrument can also be used in periodontitis patients with CAD.Methods: A total of 62 periodontitis patients with CAD were recruited along with a control group consisting of 59 age and gender matched periodontitis volunteers without systemic disorders. Using a portable optical near-infrared spectrometer, optical spectra were obtained, processed and evaluated from the two groups. A modified Beer-Lambert unmixing model that incorporates a nonparametric scattering loss function was used to determine the relative contribution of deoxygenated hemoglobin (Hb) and oxygenated hemoglobin (HbO2) to the overall spectrum. The balance between tissue oxygen delivery and utilization in periodontal tissues was then assessed.Results: Tissue oxygen saturation was significantly decreased in the periodontitis sites (p < 0.01), compared to the healthy sites in those individuals with CAD. There was a trend towards increased concentration of Hb and decreased concentration of HbO2 from healthy to diseased sites, without statistical significance (p > 0.05). No statistical differences were found in tissue oxygen saturation between the CAD and control groups either in periodontal healthy or inflammatory sites.Conclusion: This study supports the hypothesis that optical spectroscopy can determine the periodontal inflammation in patients with certain systemic disorders like CAD. And the overall periodontal oxygenation profiles in CAD patients resemble those in non-CAD individuals either in healthy or inflammatory sites. © 2014 Zhang et al.; licensee BioMed Central Ltd. |
|---|
| Date de publication | 2014 |
|---|
| Dans | |
|---|
| Langue | anglais |
|---|
| Publications évaluées par des pairs | Oui |
|---|
| Numéro NPARC | 21272264 |
|---|
| Exporter la notice | Exporter en format RIS |
|---|
| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
|---|
| Identificateur de l’enregistrement | f7b75ca7-04d4-4cd8-b3e9-31b052484181 |
|---|
| Enregistrement créé | 2014-07-23 |
|---|
| Enregistrement modifié | 2020-04-22 |
|---|
