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| DOI | Trouver le DOI : https://doi.org/10.1016/j.isci.2023.107612 |
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| Auteur | Rechercher : Perera, Dilhan J.; Rechercher : Domenech, Pilar; Rechercher : Babuadze, George Giorgi; Rechercher : Naghibosadat, Maedeh; Rechercher : Alvarez, Fernando; Rechercher : Koger-Pease, Cal; Rechercher : Labrie, Lydia; Rechercher : Stuible, Matthew1; Rechercher : Durocher, Yves1; Rechercher : Piccirillo, Ciriaco A.; Rechercher : Lametti, André; Rechercher : Fiset, Pierre Olivier; Rechercher : Elahi, Seyyed Mehdy1; Rechercher : Kobinger, Gary P.; Rechercher : Gilbert, Rénald1; Rechercher : Olivier, Martin; Rechercher : Kozak, Robert; Rechercher : Reed, Michael B.; Rechercher : Ndao, MomarIdentifiant ORCID : https://orcid.org/0000-0002-9012-4212 |
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| Affiliation | - Conseil national de recherches du Canada. Thérapeutique en santé humaine
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| Format | Texte, Article |
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| Résumé | Recent publications have explored intranasal (i.n.) adenovirus-based (Ad) vaccines as an effective strategy for SARS-CoV-2 in pre-clinical models. However, the effects of prior immunizations and infections have yet to be considered. Here, we investigate the immunomodulatory effects of Mycobacterium bovis BCG pre-immunization followed by vaccination with an S-protein-expressing i.n. Ad, termed Ad(Spike). While i.n. Ad(Spike) retains some protective effect after 6 months, a single administration of BCG-Danish prior to Ad(Spike) potentiates its ability to control viral replication of the B.1.351 SARS-CoV-2 variant within the respiratory tract. Though BCG-Danish did not affect Ad(Spike)-generated humoral immunity, it promoted the generation of cytotoxic/Th1 responses over suppressive FoxP3⁺ TREG cells in the lungs of infected mice. Thus, this vaccination strategy may prove useful in limiting future pandemics by potentiating the long-term efficacy of mucosal vaccines within the context of the widely distributed BCG vaccine. |
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| Date de publication | 2023-08-11 |
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| Maison d’édition | Elsevier |
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| Licence | |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Identificateur | S2589004223016899 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | f92e42df-d0b5-43cd-bd76-cec099f899ec |
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| Enregistrement créé | 2024-05-28 |
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| Enregistrement modifié | 2024-05-28 |
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