Chiral discrimination in the exchange of α-tocopherol stereoisomers between plasma and red blood cells

DOI	Trouver le DOI : https://doi.org/10.1007/BF02540361
Auteur	Rechercher : Cheng, S.C.¹; Rechercher : Burton, G.W.¹; Rechercher : Ingold, K. U.¹; Rechercher : Foster, D.O.¹
Affiliation	Conseil national de recherches du Canada
Format	Texte, Article
Sujet	alpha tocopherol; animal cell; animal experiment; blood and hemopoietic system; diastereoisomer; drug distribution; erythrocyte; plasma; rat; Animal; Deuterium; Erythrocytes; Kinetics; Male; Rats; Rats, Inbred Strains; Stereoisomerism; Structure-Activity Relationship; Support, Non-U.S. Gov't; Vitamin E
Résumé	The transport of 2 R,4′R, 8′R-α-tocopherol and 2 S,4′R,8′R-α-tocopherol from plasma into rat red blood cell membranes occurs with essentially no chiral discrimination. The previously demonstrated (10) preference of red blood cell membranes favoring 2 R,4′R,8′R-α-tocopherol over the 2 S,4′R, 8′R stereoisomer is shown to be due to better retention of the former compound, i.e., to preferential retention of natural vitamin E. © 1987 American Oil Chemists' Society.
Date de publication	1987
Dans	Lipids 22, nº 7 (1987) : 469–473.
Langue	anglais
Publications évaluées par des pairs	Oui
Numéro NPARC	21276724
Exporter la notice	Exporter en format RIS
Signaler une correction	Signaler une correction (s'ouvre dans un nouvel onglet)
Identificateur de l’enregistrement	f9f6288b-b789-4e6f-a287-590371ffa917
Enregistrement créé	2015-10-13
Enregistrement modifié	2020-03-17