| Téléchargement | - Voir la version finale : Analysis of low-scattering regions in optical coherence tomography: applications to neurography and lymphangiography (PDF, 5.0 Mio)
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| DOI | Trouver le DOI : https://doi.org/10.1364/BOE.10.004207 |
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| Auteur | Rechercher : Demidov, Valentin; Rechercher : Matveev, Lev A.; Rechercher : Demidova, Olga; Rechercher : Matveyev, Alexander L.; Rechercher : Zaitsev, Vladimir Y.; Rechercher : Flueraru, Costel1; Rechercher : Vitkin, I. Alex |
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| Affiliation | - Conseil national de recherches du Canada. Électronique et photonique avancées
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| Format | Texte, Article |
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| Résumé | Analysis of semi-transparent low scattering biological structures in optical coherence tomography (OCT) has been actively pursued in the context of lymphatic imaging, with most approaches relying on the relative absence of signal as a means of detection. Here we present an alternate methodology based on spatial speckle statistics, utilizing the similarity of a distribution of given voxel intensities to the power distribution function of pure noise, to visualize the low-scattering biological structures of interest. In a human tumor xenograft murine model, we show that these correspond to lymphatic vessels and nerves; extensive histopathologic validation studies are reported to unequivocally establish this correspondence. The emerging possibility of OCT lymphangiography and neurography is novel and potentially impactful (especially the latter), although further methodology refinement is needed to distinguish between the visualized lymphatics and nerves. |
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| Date de publication | 2019-07-26 |
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| Maison d’édition | Optical Society of America |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | fa01f113-cf7b-429f-b90b-14c7f957b9ed |
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| Enregistrement créé | 2020-11-20 |
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| Enregistrement modifié | 2020-12-23 |
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