| DOI | Trouver le DOI : https://doi.org/10.1016/j.cbpa.2014.05.023 |
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| Auteur | Rechercher : MacKenzie, Douglas A.1; Rechercher : Sherratt, Allison R.1; Rechercher : Chigrinova, Mariya1; Rechercher : Cheung, Lawrence L. W.1; Rechercher : Pezacki, John Paul1 |
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| Affiliation | - Conseil national de recherches du Canada. Dispositifs médicaux
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| Format | Texte, Article |
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| Sujet | alkyne derivative; nitrone derivative; chemical reaction kinetics; cycloaddition; strain promoted alkyne nitrone cycloaddition |
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| Résumé | The development and applications of strain-promoted alkyne-nitrone cycloaddition (SPANC) reactions have brought about new tools for rapid and specific functionalization of biomolecules in different settings. While a number of strain-promoted reactions have been successfully developed, SPANC reactions offer high reactivity with bimolecular rate constants of k2 that are as fast as 60M-1s-1. SPANC reactions also offer stability of starting materials, particularly in the case of endocyclic nitrones, as well as stereoelectronic tunability of the nitrone moiety to optimize reactivity towards different alkyne reaction partners. Herein we discuss recent advances in the development of SPANC reactions and their applications in bioorthogonal labeling. |
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| Date de publication | 2014-08 |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro NPARC | 21272874 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | faea30eb-c180-4c9c-bf46-e720941580de |
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| Enregistrement créé | 2014-12-03 |
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| Enregistrement modifié | 2020-04-22 |
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