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| DOI | Trouver le DOI : https://doi.org/10.1016/j.toxicon.2023.107086 |
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| Auteur | Rechercher : McCarron, Pearse1Identifiant ORCID : https://orcid.org/0000-0002-7746-8432; Rechercher : Rafuse, Cheryl1; Rechercher : Scott, Steven; Rechercher : Lawrence, Janice; Rechercher : Bruce, Meghann R.; Rechercher : Douthwright, Erin; Rechercher : Murphy, Colleen2; Rechercher : Reith, Michael2; Rechercher : Beach, Daniel G.1 |
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| Affiliation | - Conseil national de recherches du Canada. Centre de recherche en métrologie
- Conseil national de recherches du Canada. Développement des cultures et des ressources aquatiques
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| Bailleur de fonds | Rechercher : National Research Council Canada; Rechercher : Environmental Trust Fund, Government of New Brunswick |
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| Format | Texte, Article |
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| Sujet | cyanotoxins; anatoxin; dog mortalities; LC-HRMS; Microcoleus |
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| Résumé | In July 2018 three dogs died after visiting the Wolastoq (Saint John River) near Fredericton, New Brunswick, in Atlantic Canada. All showed signs of toxicosis, and necropsies revealed non-specific pulmonary edema and multiple microscopic brain hemorrhages. Liquid chromatography–high-resolution mass spectrometry (LC–HRMS) analysis of vomitus and stomach contents as well as water and biota from the mortality sites confirmed the presence of anatoxins (ATXs), a class of potent neurotoxic alkaloids. The highest levels were measured in a dried benthic cyanobacterial mat that two of the dogs had been eating before falling ill and in a vomitus sample collected from one of the dogs. Concentrations of 357 and 785 mg/kg for anatoxin-a and dihydroanatoxin-a, respectively, were measured in the vomitus. Known anatoxin-producing species of Microcoleus were tentatively identified using microscopy and confirmed by 16S rRNA gene sequencing. The ATX synthetase gene, anaC, was detected in the samples and isolates. The pathology and experimental results confirmed the role of ATXs in these dog mortalities. Further research is required to understand drivers for toxic cyanobacteria in the Wolastoq and to develop methodology for assessing occurrence. |
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| Date de publication | 2023-03-11 |
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| Maison d’édition | Elsevier |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | fcbd7182-bce1-4691-a748-3579fd3b5ceb |
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| Enregistrement créé | 2023-06-06 |
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| Enregistrement modifié | 2024-01-11 |
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