| DOI | Resolve DOI: https://doi.org/10.1016/j.jprot.2021.104369 |
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| Author | Search for: Li, Henghui; Search for: Zhang, Xu; Search for: Chen, Rui1; Search for: Cheng, Kai; Search for: Ning, Zhibin; Search for: Li, Jianjun1; Search for: Twine, Susan1; Search for: Stintzi, Alain; Search for: Mack, David; Search for: Figeys, Daniel |
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| Affiliation | - National Research Council of Canada. Human Health Therapeutics
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| Format | Text, Article |
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| Subject | glycomics; intestinal microbiota; N-glycan; paucimannosidic glycan; Ulcerative colitis |
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| Abstract | Pediatric ulcerative colitis (UC) is a distinct type of inflammatory bowel disease with severe disease activity and rapid progression, which can lead to detrimental life-long consequences. The pathogenesis of pediatric UC remains unclear, although dysbiosis of the gut microbiota has been considered an important factor. In this study, we collected intestinal mucosal-luminal interface microbiota samples from a cohort of treatment-naïve pediatric UC or control patients and used two different mass spectrometry-based glycomic approaches to examine the N-glycans that were associated with the microbiota. We observed abundant small N-glycans that were associated with the microbiota and found that the pediatric UC microbiota samples contained significantly higher levels of these atypical N-glycans compared to those of controls. Four paucimannosidic or other truncated N-glycans were identified to successfully segregate UC from control patients with an area under the ROC curve of ≥0.9. This study indicates that the aberrant metabolism of glycans in the intestinal by gut microbiota may be involved in the pathogenesis of UC and intestinal N-glycans, including small glycans, can act as novel biomarker candidates for pediatric UC. |
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| Publication date | 2021-09-03 |
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| Publisher | Elsevier |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| Identifier | S1874391921002682 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 05d9ccb1-f6f5-4aec-803f-6e785d4bc41c |
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| Record created | 2023-01-13 |
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| Record modified | 2023-01-13 |
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