| DOI | Trouver le DOI : https://doi.org/10.1016/j.jprot.2021.104369 |
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| Auteur | Rechercher : Li, Henghui; Rechercher : Zhang, Xu; Rechercher : Chen, Rui1; Rechercher : Cheng, Kai; Rechercher : Ning, Zhibin; Rechercher : Li, Jianjun1; Rechercher : Twine, Susan1; Rechercher : Stintzi, Alain; Rechercher : Mack, David; Rechercher : Figeys, Daniel |
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| Affiliation | - Conseil national de recherches du Canada. Thérapeutique en santé humaine
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| Format | Texte, Article |
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| Sujet | glycomics; intestinal microbiota; N-glycan; paucimannosidic glycan; Ulcerative colitis |
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| Résumé | Pediatric ulcerative colitis (UC) is a distinct type of inflammatory bowel disease with severe disease activity and rapid progression, which can lead to detrimental life-long consequences. The pathogenesis of pediatric UC remains unclear, although dysbiosis of the gut microbiota has been considered an important factor. In this study, we collected intestinal mucosal-luminal interface microbiota samples from a cohort of treatment-naïve pediatric UC or control patients and used two different mass spectrometry-based glycomic approaches to examine the N-glycans that were associated with the microbiota. We observed abundant small N-glycans that were associated with the microbiota and found that the pediatric UC microbiota samples contained significantly higher levels of these atypical N-glycans compared to those of controls. Four paucimannosidic or other truncated N-glycans were identified to successfully segregate UC from control patients with an area under the ROC curve of ≥0.9. This study indicates that the aberrant metabolism of glycans in the intestinal by gut microbiota may be involved in the pathogenesis of UC and intestinal N-glycans, including small glycans, can act as novel biomarker candidates for pediatric UC. |
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| Date de publication | 2021-09-03 |
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| Maison d’édition | Elsevier |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Identificateur | S1874391921002682 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 05d9ccb1-f6f5-4aec-803f-6e785d4bc41c |
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| Enregistrement créé | 2023-01-13 |
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| Enregistrement modifié | 2023-01-13 |
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