| DOI | Resolve DOI: https://doi.org/10.1016/j.carres.2012.11.004 |
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| Author | Search for: Kubler-Kielb, J.; Search for: Vinogradov, E.1 |
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| Affiliation | - National Research Council of Canada
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| Format | Text, Article |
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| Subject | Brucella; Core part; Host-cell invasion; Human pathogens; Immune systems; Intracellular survival; Lipopolysaccharides; Low toxicity; LPS; MS; O-Antigen; Reducing ends; Spectroscopic method; Virulence factors; Nuclear magnetic resonance; Organic compounds; Structure (composition); Synthesis (chemical); Spectroscopic analysis; lipopolysaccharide; O antigen; antimicrobial activity; Brucella; chemical analysis; immune system; spectroscopy; structure analysis; Animalia; Brucella |
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| Abstract | Brucella is an animal and human pathogen that expresses several virulence factors required for host cell invasion and intracellular survival. It produces LPS with unusually low toxicity, which hampers the detection of bacteria by the host immune system and thus provides resistance against intracellular antimicrobial mechanisms of the host. By chemical and spectroscopic methods we determined the structure of the LPS core and of a non-repetitive oligosaccharide fragment at the reducing end of the O-specific polysaccharide. These data should be useful for understanding the biological role of the Brucella LPS. Crown Copyright © 2012 Published by Elsevier Ltd. All rights reserved. |
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| Publication date | 2013 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 21270668 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 0630e6b2-d834-48ff-ae1a-62b437312723 |
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| Record created | 2014-02-17 |
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| Record modified | 2020-04-22 |
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